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Intestinal α-Glucosidase Inhibitors in Achillea millefolium

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Title: Intestinal α-Glucosidase Inhibitors in Achillea millefolium
Authors: Noda, Kota Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Diabetes
Intestinal α-glucosidase
Glucosidase inhibitor
Caffeoylquinic acid
Issue Date: 1-Aug-2017
Publisher: SAGE
Journal Title: Natural Product Communications
Volume: 12
Issue: 8
Start Page: 1259
End Page: 1261
Publisher DOI: 10.1177/1934578X1701200828
Abstract: Achillea millefolium is a plant used as a component of anti-diabetic preparation but the bioactive compounds responsible for its use are not known. Inhibition of intestinal α-glucosidase is a preferable effect for prevention and treatment of diabetes, and A. millefolium extract showed inhibitory activity against the enzyme. Activity-guided separation of the extract gave four mono- or di-caffeoylquinic acids as the isolate. Quantitation of these four caffeoylquinic acids and the activity of the isolates suggested that these are the major contributor for the α-glucosidase inhibitory activity in the extract. However also, the presence of unidentified, minor, but potent α-glucosidase inhibitor in the isolate was also suggested.
Rights: Kota Noda, Eisuke Kato, Jun Kawabata, Intestinal α-Glucosidase Inhibitors in Achillea millefolium, Natural Product Communications (Vol12 No.8) pp. 1259-1261. Copyright © 2017(SAGE). DOI:10.1177/1934578X1701200828.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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