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MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation

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Title: MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation
Authors: Xu, Daozhi Browse this author
Dong, Peixin Browse this author →KAKEN DB
Xiong, Ying Browse this author
Yue, Junming Browse this author
Ihira, Kei Browse this author →KAKEN DB
Konno, Yosuke Browse this author →KAKEN DB
Kobayashi, Noriko Browse this author
Todo, Yukiharu Browse this author →KAKEN DB
Watari, Hidemichi Browse this author →KAKEN DB
Keywords: microRNA-361
tumor microenvironment
cancer diagnosis
cancer treatment
Issue Date: Aug-2019
Publisher: MDPI
Journal Title: Cancers
Volume: 11
Issue: 8
Start Page: 1130
Publisher DOI: 10.3390/cancers11081130
Abstract: MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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