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MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation |
| Authors: | Xu, Daozhi Browse this author | | Dong, Peixin Browse this author →KAKEN DB | | Xiong, Ying Browse this author | | Yue, Junming Browse this author | | Ihira, Kei Browse this author →KAKEN DB | | Konno, Yosuke Browse this author →KAKEN DB | | Kobayashi, Noriko Browse this author | | Todo, Yukiharu Browse this author →KAKEN DB | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | microRNA-361 | | EMT | | angiogenesis | | tumor microenvironment | | cancer diagnosis | | cancer treatment |
| Issue Date: | Aug-2019 |
| Publisher: | MDPI |
| Journal Title: | Cancers |
| Volume: | 11 |
| Issue: | 8 |
| Start Page: | 1130 |
| Publisher DOI: | 10.3390/cancers11081130 |
| Abstract: | MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75182 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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