| Title: | Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma |
| Authors: | Kuwabara, Shota Browse this author |
| Tsuchikawa, Takahiro Browse this author →KAKEN DB |
| Nakamura, Toru Browse this author →KAKEN DB |
| Hatanaka, Yutaka Browse this author →KAKEN DB |
| Hatanaka, Kanako C. Browse this author |
| Sasaki, Katsunori Browse this author →KAKEN DB |
| Ono, Masato Browse this author |
| Umemoto, Kazufumi Browse this author |
| Suzuki, Tomohiro Browse this author |
| Sato, Osamu Browse this author |
| Hane, Yuma Browse this author |
| Nakanishi, Yoshitsugu Browse this author →KAKEN DB |
| Asano, Toshimichi Browse this author →KAKEN DB |
| Ebihara, Yuma Browse this author →KAKEN DB |
| Kurashima, Yo Browse this author →KAKEN DB |
| Noji, Takehiro Browse this author →KAKEN DB |
| Murakami, Soichi Browse this author →KAKEN DB |
| Okamura, Keisuke Browse this author →KAKEN DB |
| Shichinohe, Toshiaki Browse this author →KAKEN DB |
| Hirano, Satoshi Browse this author →KAKEN DB |
| Keywords: | chemoradiotherapy |
| immunology |
| neoadjuvant |
| pancreatic cancer |
| tumor microenvironment |
| Issue Date: | Jun-2019 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Cancer science |
| Volume: | 110 |
| Issue: | 6 |
| Start Page: | 1853 |
| End Page: | 1862 |
| Publisher DOI: | 10.1111/cas.14023 |
| PMID: | 30997706 |
| Abstract: | The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLO) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. We retrospectively investigated the clinical relevance of TLO by categorizing patients into those who underwent upfront surgery (surgery first [SF]) and those who received NAC. The immunological elements within TLO were analyzed by immunohistochemistry (IHC). In the IHC analysis, the proportions of CD8+ T lymphocytes, PNAd+ high endothelial venules, CD163+ macrophages and Ki-67+ cells within the TLO were higher in the NAC group than in the SF group. In contrast, the proportion of programmed cell death-1+ immunosuppressive lymphocytes within TLO was lower in the NAC group than in the SF group. The NAC group demonstrated favorable prognoses compared with the SF group. In the multivariate analysis, the TLO/tumor ratio was determined as an independent predictive prognostic factor. In conclusion, the administration of preoperative chemoradiotherapy may influence the immunological elements in the tumor microenvironment and result in favorable prognoses in pancreatic ductal adenocarcinoma patients. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75208 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
