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Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma

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Title: Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma
Authors: Kuwabara, Shota Browse this author
Tsuchikawa, Takahiro Browse this author →KAKEN DB
Nakamura, Toru Browse this author →KAKEN DB
Hatanaka, Yutaka Browse this author →KAKEN DB
Hatanaka, Kanako C. Browse this author
Sasaki, Katsunori Browse this author →KAKEN DB
Ono, Masato Browse this author
Umemoto, Kazufumi Browse this author
Suzuki, Tomohiro Browse this author
Sato, Osamu Browse this author
Hane, Yuma Browse this author
Nakanishi, Yoshitsugu Browse this author →KAKEN DB
Asano, Toshimichi Browse this author →KAKEN DB
Ebihara, Yuma Browse this author →KAKEN DB
Kurashima, Yo Browse this author →KAKEN DB
Noji, Takehiro Browse this author →KAKEN DB
Murakami, Soichi Browse this author →KAKEN DB
Okamura, Keisuke Browse this author →KAKEN DB
Shichinohe, Toshiaki Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: chemoradiotherapy
immunology
neoadjuvant
pancreatic cancer
tumor microenvironment
Issue Date: Jun-2019
Publisher: John Wiley & Sons
Journal Title: Cancer science
Volume: 110
Issue: 6
Start Page: 1853
End Page: 1862
Publisher DOI: 10.1111/cas.14023
PMID: 30997706
Abstract: The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLO) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. We retrospectively investigated the clinical relevance of TLO by categorizing patients into those who underwent upfront surgery (surgery first [SF]) and those who received NAC. The immunological elements within TLO were analyzed by immunohistochemistry (IHC). In the IHC analysis, the proportions of CD8+ T lymphocytes, PNAd+ high endothelial venules, CD163+ macrophages and Ki-67+ cells within the TLO were higher in the NAC group than in the SF group. In contrast, the proportion of programmed cell death-1+ immunosuppressive lymphocytes within TLO was lower in the NAC group than in the SF group. The NAC group demonstrated favorable prognoses compared with the SF group. In the multivariate analysis, the TLO/tumor ratio was determined as an independent predictive prognostic factor. In conclusion, the administration of preoperative chemoradiotherapy may influence the immunological elements in the tumor microenvironment and result in favorable prognoses in pancreatic ductal adenocarcinoma patients.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/75208
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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