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Hokkaido University Collection of Scholarly and Academic Papers >
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Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications
| Title: | Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications |
| Authors: | Ye, Ya Nan Browse this author | | Frauenlob, Martin Browse this author | | Wang, Lei Browse this author →KAKEN DB | | Tsuda, Masumi Browse this author →KAKEN DB | | Sun, Tao Lin Browse this author | | Cui, Kunpeng Browse this author | | Takahashi, Riku Browse this author | | Zhang, Hui Jie Browse this author | | Nakajima, Tasuku Browse this author | | Nonoyama, Takayuki Browse this author →KAKEN DB | | Kurokawa, Takayuki Browse this author →KAKEN DB | | Tanaka, Shinya Browse this author →KAKEN DB | | Gong, Jian Ping Browse this author →KAKEN DB |
| Keywords: | Tough and thin hydrogel membrane | | Self-recovery | | Biocompatibility | | Biological membrane | | Anti-adhesive membrane |
| Issue Date: | 1-Aug-2018 |
| Publisher: | Wiley |
| Journal Title: | Advanced functional materials |
| Volume: | 28 |
| Issue: | 31 |
| Start Page: | 1801489 |
| Publisher DOI: | 10.1002/adfm.201801489 |
| Abstract: | Tough and self‐recoverable hydrogel membranes with micrometer‐scale thickness are promising for biomedical applications, which, however, rarely be realized due to the intrinsic brittleness of hydrogels. In this work, for the first time, by combing noncovalent DN strategy and spin‐coating method, we successfully fabricated thin (thickness: 5–100 µm), yet tough (work of extension at fracture: 105–107 J m−3) and 100% self‐recoverable hydrogel membranes with high water content (62–97 wt%) in large size (≈100 cm2). Amphiphilic triblock copolymers, which form physical gels by self‐assembly, were used for the first network. Linear polymers that physically associate with the hydrophilic midblocks of the first network, were chosen for the second network. The inter‐network associations serve as reversible sacrificial bonds that impart toughness and self‐recovery properties on the hydrogel membranes. The excellent mechanical properties of these obtained tough and thin gel membranes are comparable, or even superior to many biological membranes. The in vitro and in vivo tests show that these hydrogel membranes are biocompatible, and postoperative nonadhesive to neighboring organs. The excellent mechanical and biocompatible properties make these thin hydrogel membranes potentially suitable for use as biological or postoperative antiadhesive membranes. |
| Rights: | This is the peer reviewed version of the following article: [Ya Nan Ye, Martin Frauenlob, Lei Wang, Masumi Tsuda, Tao Lin Sun, Kunpeng Cui, Riku Takahashi, Hui Jie Zhang, Tasuku Nakajima, Takayuki Nonoyama, Takayuki Kurokawa, Shinya Tanaka, and Jian Ping Gong, Tough and Self‐Recoverable Thin Hydrogel Membranes for Biological Applications, Advanced Functional Materials 2018, 28, 1801489], which has been published in final form at [https://doi.org/10.1002/adfm.201801489]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/75209 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 龔 剣萍 (Gong Jian Ping)
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