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Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/75209

Title: Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications
Authors: Ye, Ya Nan Browse this author
Frauenlob, Martin Browse this author
Wang, Lei Browse this author →KAKEN DB
Tsuda, Masumi Browse this author →KAKEN DB
Sun, Tao Lin Browse this author
Cui, Kunpeng Browse this author
Takahashi, Riku Browse this author
Zhang, Hui Jie Browse this author
Nakajima, Tasuku Browse this author
Nonoyama, Takayuki Browse this author →KAKEN DB
Kurokawa, Takayuki Browse this author →KAKEN DB
Tanaka, Shinya Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Keywords: Tough and thin hydrogel membrane
Self-recovery
Biocompatibility
Biological membrane
Anti-adhesive membrane
Issue Date: 1-Aug-2018
Publisher: Wiley
Journal Title: Advanced functional materials
Volume: 28
Issue: 31
Start Page: 1801489
Publisher DOI: 10.1002/adfm.201801489
Abstract: Tough and self‐recoverable hydrogel membranes with micrometer‐scale thickness are promising for biomedical applications, which, however, rarely be realized due to the intrinsic brittleness of hydrogels. In this work, for the first time, by combing noncovalent DN strategy and spin‐coating method, we successfully fabricated thin (thickness: 5–100 µm), yet tough (work of extension at fracture: 105–107 J m−3) and 100% self‐recoverable hydrogel membranes with high water content (62–97 wt%) in large size (≈100 cm2). Amphiphilic triblock copolymers, which form physical gels by self‐assembly, were used for the first network. Linear polymers that physically associate with the hydrophilic midblocks of the first network, were chosen for the second network. The inter‐network associations serve as reversible sacrificial bonds that impart toughness and self‐recovery properties on the hydrogel membranes. The excellent mechanical properties of these obtained tough and thin gel membranes are comparable, or even superior to many biological membranes. The in vitro and in vivo tests show that these hydrogel membranes are biocompatible, and postoperative nonadhesive to neighboring organs. The excellent mechanical and biocompatible properties make these thin hydrogel membranes potentially suitable for use as biological or postoperative antiadhesive membranes.
Rights: This is the peer reviewed version of the following article: [Ya Nan Ye, Martin Frauenlob, Lei Wang, Masumi Tsuda, Tao Lin Sun, Kunpeng Cui, Riku Takahashi, Hui Jie Zhang, Tasuku Nakajima, Takayuki Nonoyama, Takayuki Kurokawa, Shinya Tanaka, and Jian Ping Gong, Tough and Self‐Recoverable Thin Hydrogel Membranes for Biological Applications, Advanced Functional Materials 2018, 28, 1801489], which has been published in final form at [https://doi.org/10.1002/adfm.201801489]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/75209
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 龔 剣萍 (Gong Jian Ping)

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