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Proinsulin is sensitive to reflect glucose intolerance

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Title: Proinsulin is sensitive to reflect glucose intolerance
Authors: Nakamura, Akinobu Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Ukawa, Shigekazu Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Nakagawa, Takafumi Browse this author
Terauchi, Yasuo Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: beta-Cell function
Issue Date: 21-Jun-2019
Publisher: John Wiley & Sons
Journal Title: Journal of diabetes investigation
Publisher DOI: 10.1111/jdi.13106
PMID: 31222973
Abstract: Aims/Introduction We investigated associations between glucose tolerance and beta-cell function using a series of estimation methods in a population-based study. Materials and Methods Data from the Dynamics of Lifestyle and Neighborhood Community on Health Study were analyzed. A total of 489 participants (263 women) were divided into three groups: normal glucose tolerance (NGT), prediabetes (PDM) and diabetes group. We estimated beta-cell function by the homeostasis model assessment of beta-cell function, proinsulin level (PI), C-peptide index, proinsulin-to-C-peptide ratio (PI/CPR) and proinsulin-to-insulin ratio. Because data on all five parameters of beta-cell function showed skewed distributions, the values of these parameters were normalized by natural logarithmic (ln) transformation. Next, the association between glucose tolerance and beta-cell function among participants without diabetes was examined. In this analysis, glucose tolerance was assessed based on glycated hemoglobin levels. Results In the crude analysis, ln(PI) and ln(PI/CPR) were significantly higher in the diabetes group than those in the PDM and NGT groups, and these parameters were significantly higher in the PDM group than in the NGT group. Only ln(PI) in the PDM group was significantly higher compared with that in the NGT group after adjustment for age, sex and body mass index (ln[PI]: PDM group 2.38 pmol/L, 95% confidence interval 2.29-2.47 pmol/L; NGT group 2.17 pmol/L, 95% confidence interval 2.12-2.22 pmol/L; P < 0.05). In addition, ln(PI) levels were significantly and positively correlated with glycated hemoglobin quartile in participants without diabetes. Conclusions Our results showed that PI was the most sensitive to reflect glucose intolerance.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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