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Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study

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Title: Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study
Authors: Konishi, Takao Browse this author
Kashiwagi, Yusuke Browse this author
Funayama, Naohiro Browse this author
Yamamoto, Tadashi Browse this author
Murakami, Hironori Browse this author
Hotta, Daisuke Browse this author
Tanaka, Shinya Browse this author →KAKEN DB
Keywords: Obstructive sleep apnea
Plaque instability
Optical frequency domain imaging
Issue Date: Aug-2019
Publisher: Springer
Journal Title: Heart and vessels
Volume: 34
Issue: 8
Start Page: 1266
End Page: 1279
Publisher DOI: 10.1007/s00380-019-01363-8
PMID: 30790035
Abstract: Obstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). We retrospectively analyzed OFDI data for coronary artery plaques from 15 patients with OSA and 35 non-OSA patients treated between October 2015 and October 2018. Plaque morphology was evaluated for 70 lesions, including 21 from patients with OSA and 49 from non-OSA patients. Compared with the non-OSA group, patients with OSA had significantly higher prevalences of thinned cap fibroatheroma (TCFA) (67% vs. 35%, P=0.014) and microchannels (86% vs. 55%, P=0.014); a significantly higher mean lipid index (1392 +/- 982 vs. 817 +/- 699, P=0.021), macrophage grade (8.4 +/- 6.4 vs. 4.8 +/- 4.5, P=0.030), and maximum number of microchannels (1.5 +/- 1.0 vs. 0.7 +/- 0.7, P=0.001); and a significantly lower mean minimum fibrous cap thickness (69.4 +/- 28.7 vs. 96.1 +/- 51.8 mu m, P=0.008). This OFDI analysis suggests that OSA is associated with unstable plaque characteristics in patients with CAD. More intensive medical management for stabilization of coronary atherosclerotic plaque is required in patients with OSA.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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