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Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study |
| Authors: | Konishi, Takao Browse this author | | Kashiwagi, Yusuke Browse this author | | Funayama, Naohiro Browse this author | | Yamamoto, Tadashi Browse this author | | Murakami, Hironori Browse this author | | Hotta, Daisuke Browse this author | | Tanaka, Shinya Browse this author →KAKEN DB |
| Keywords: | Obstructive sleep apnea | | Plaque instability | | Optical frequency domain imaging |
| Issue Date: | Aug-2019 |
| Publisher: | Springer |
| Journal Title: | Heart and vessels |
| Volume: | 34 |
| Issue: | 8 |
| Start Page: | 1266 |
| End Page: | 1279 |
| Publisher DOI: | 10.1007/s00380-019-01363-8 |
| PMID: | 30790035 |
| Abstract: | Obstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). We retrospectively analyzed OFDI data for coronary artery plaques from 15 patients with OSA and 35 non-OSA patients treated between October 2015 and October 2018. Plaque morphology was evaluated for 70 lesions, including 21 from patients with OSA and 49 from non-OSA patients. Compared with the non-OSA group, patients with OSA had significantly higher prevalences of thinned cap fibroatheroma (TCFA) (67% vs. 35%, P=0.014) and microchannels (86% vs. 55%, P=0.014); a significantly higher mean lipid index (1392 +/- 982 vs. 817 +/- 699, P=0.021), macrophage grade (8.4 +/- 6.4 vs. 4.8 +/- 4.5, P=0.030), and maximum number of microchannels (1.5 +/- 1.0 vs. 0.7 +/- 0.7, P=0.001); and a significantly lower mean minimum fibrous cap thickness (69.4 +/- 28.7 vs. 96.1 +/- 51.8 mu m, P=0.008). This OFDI analysis suggests that OSA is associated with unstable plaque characteristics in patients with CAD. More intensive medical management for stabilization of coronary atherosclerotic plaque is required in patients with OSA. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75268 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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