High-performance catalysts are often composed of two or more active phases, which are believed to interact with each other at the mesoscopic scale structure. Unlike conventional powder catalysts flat surfaces is advantageous in that its surface structure can be precisely designed. We prepared precisely designed Sb2O4/VSbO4/Si catalysts containing Sb2O4 ribbons with finely controlled width and separation by electron lithography. We demonstrated that the acrolein generation rate on the catalysts was related to the width and separation of the Sb2O4 ribbons. This work shows the possibility to regulate catalyses by inhomogeneity of the surface structure at the mesoscopic level.