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Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia
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| Title: | Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia |
| Authors: | Lahrita, Lucy Browse this author | | Hirosawa, Ryota Browse this author | | Kato, Eisuke Browse this author →KAKEN DB | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | 3T3-L1 adipocytes | | Eurycoma longifolia | | Lipolysis | | Obesity | | Quassinoid |
| Issue Date: | 1-Sep-2017 |
| Publisher: | Elsevier |
| Journal Title: | Bioorganic and Medicinal Chemistry |
| Volume: | 25 |
| Issue: | 17 |
| Start Page: | 4829 |
| End Page: | 4834 |
| Publisher DOI: | 10.1016/j.bmc.2017.07.032 |
| PMID: | 28760530 |
| Abstract: | Eurycomanone (1) and 13β,21-epoxyeurycomanone (2) were isolated from Eurycoma longifolia for studies of lipolytic activity. Compound 1 enhanced lipolysis in adipocytes with an EC₅₀ of 14.6μM, while its epoxy derivate, compound 2, had a stronger activity with an EC₅₀ of 8.6μM. Based on molecular mechanistic study using several specific inhibitors to lipolytic signaling pathways, it was found that PKA inhibitor totally diminished the lipolytic activity of 1 and 2. Further immunoblotting analysis confirmed the activation of phosphorylated PKA by both 1 and 2. With the growing need to develop new anti-obesity agents, eurycomanone and its epoxy derivate can be used as promising lead compounds to target lipid catabolism. |
| Rights: | © 2017, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/75320 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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