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Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia

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Title: Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia
Authors: Lahrita, Lucy Browse this author
Hirosawa, Ryota Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: 3T3-L1 adipocytes
Eurycoma longifolia
Lipolysis
Obesity
Quassinoid
Issue Date: 1-Sep-2017
Publisher: Elsevier
Journal Title: Bioorganic and Medicinal Chemistry
Volume: 25
Issue: 17
Start Page: 4829
End Page: 4834
Publisher DOI: 10.1016/j.bmc.2017.07.032
PMID: 28760530
Abstract: Eurycomanone (1) and 13β,21-epoxyeurycomanone (2) were isolated from Eurycoma longifolia for studies of lipolytic activity. Compound 1 enhanced lipolysis in adipocytes with an EC₅₀ of 14.6μM, while its epoxy derivate, compound 2, had a stronger activity with an EC₅₀ of 8.6μM. Based on molecular mechanistic study using several specific inhibitors to lipolytic signaling pathways, it was found that PKA inhibitor totally diminished the lipolytic activity of 1 and 2. Further immunoblotting analysis confirmed the activation of phosphorylated PKA by both 1 and 2. With the growing need to develop new anti-obesity agents, eurycomanone and its epoxy derivate can be used as promising lead compounds to target lipid catabolism.
Rights: © 2017, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/75320
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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