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Identification of group A rotaviruses from Zambian fruit bats provides evidence for long-distance dispersal events in Africa

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Title: Identification of group A rotaviruses from Zambian fruit bats provides evidence for long-distance dispersal events in Africa
Authors: Sasaki, Michihito1 Browse this author →KAKEN DB
Kajihara, Masahiro2 Browse this author →KAKEN DB
Changula, Katendi3 Browse this author
Kajihara, Akina4 Browse this author
Ogawa, Hirohito5 Browse this author →KAKEN DB
Hang'ombe, Bernard M.6 Browse this author
Mweene, Aaron S.7 Browse this author
Simuunza, Martin8 Browse this author
Yoshida, Reiko9 Browse this author →KAKEN DB
Carr, Michael10 Browse this author →KAKEN DB
Orba, Yasuko11 Browse this author →KAKEN DB
Takada, Ayato12 Browse this author →KAKEN DB
Sawa, Hirofumi13 Browse this author →KAKEN DB
Authors(alt): Mori, Akina4
Keywords: Rotavirus
African fruit bats
Long-distance dispersal
Interspecies transmission
Phylogenetic analysis
Novel RVA genotypes
Issue Date: Sep-2018
Publisher: Elsevier
Journal Title: Infection, genetics and evolution
Volume: 63
Start Page: 104
End Page: 109
Publisher DOI: 10.1016/j.meegid.2018.05.016
PMID: 29792990
Abstract: Group A rotavirus (RVA) is a major cause of diarrhea in children worldwide. Although RVA infects many animals, little is known about RVA in bats. The present study investigated the genetic diversity of RVA in Zambian bats. We identified RVA from two straw-colored fruit bats (Eidolon helvum) and an Egyptian fruit bat (Rousettus aegyptiacus), and analyzed the genome sequences of these strains. Genome segments of the RVA strains from Zambian E. helvum showed 97%–99% nucleotide sequence identity with those of other RVA strains from E. helvum in Cameroon, which is 2800 km from the sampling locations. These findings suggest that migratory straw-colored fruit bat species, distributed across sub-Saharan Africa, have the potential to disseminate RVA across long distances. By contrast, the RVA strain from Zambian R. aegyptiacus carried highly divergent NSP2 and NSP4 genes, leading us to propose novel genotypes N21 and E27, respectively. Notably, this RVA strain also shared the same genotype for VP6 and NSP3 with the RVA strains from Zambian E. helvum, suggesting interspecies transmission and genetic reassortment may have occurred between these two bat species in the past. Our study has important implications for RVA dispersal in bat populations, and expands our knowledge of the ecology, diversity and evolutionary relationships of RVA.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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