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Design, development of water tank-type lung phantom and dosimetric verification in institutions participating in a phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial (JCOG0702)

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Title: Design, development of water tank-type lung phantom and dosimetric verification in institutions participating in a phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial (JCOG0702)
Authors: Nishio, Teiji Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Ishikawa, Masayori Browse this author →KAKEN DB
Miyabe, Yuki Browse this author →KAKEN DB
Kito, Satoshi Browse this author
Narita, Yuichirou Browse this author
Onimaru, Rikiya Browse this author →KAKEN DB
Ishikura, Satoshi Browse this author →KAKEN DB
Ito, Yoshinori Browse this author →KAKEN DB
Hiraoka, Masahiro Browse this author →KAKEN DB
Keywords: Visiting dose verification
Water tank-type lung phantom
Lung SBRT clinical trial
JCOG0702
Issue Date: May-2014
Publisher: Oxford University Press
Journal Title: Journal of radiation research
Volume: 55
Issue: 3
Start Page: 600
End Page: 607
Publisher DOI: 10.1093/jrr/rrt135
PMID: 24385469
Abstract: A domestic multicenter phase I study of stereotactic body radiotherapy (SBRT) for T2N0M0 non-small cell lung cancer in inoperable patients or elderly patients who refused surgery was initiated as the Japan Clinical Oncology Group trial (JCOG0702) in Japan. Prior to the clinical study, the accuracy of dose calculation in radiation treatment-planning systems was surveyed in participating institutions, and differences in the irradiating dose between the institutions were investigated. We developed a water tank-type lung phantom appropriate for verification of the exposure dose in lung SBRT. Using this water tank-type lung phantom, the dose calculated in the radiation treatment-planning system and the measured dose using a free air ionization chamber and dosimetric film were compared in a visiting survey of the seven institutions participating in the clinical study. In all participating institutions, differences between the calculated and the measured dose in the irradiation plan were as follows: the accuracy of the absolute dose in the center of the simulated tumor measured using a free air ionization chamber was within 2%, the mean gamma value was ≤0.47 on gamma analysis following the local dose criteria, and the pass rate was >87% for 3%/3 mm from measurement of dose distribution with dosimetric film. These findings confirmed the accuracy of delivery doses in the institutions participating in the clinical study, so that a study with integration of the institutions could be initiated.
Rights: https://creativecommons.org/licenses/by-nc/3.0/
Type: article
URI: http://hdl.handle.net/2115/75483
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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