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Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan

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Title: Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan
Authors: Mizumoto, Masashi Browse this author →KAKEN DB
Murayama, Shigeyuki Browse this author →KAKEN DB
Akimoto, Tetsuo Browse this author →KAKEN DB
Demizu, Yusuke Browse this author
Fukushima, Takashi Browse this author
Ishida, Yuji Browse this author
Oshiro, Yoshiko Browse this author →KAKEN DB
Numajiri, Haruko Browse this author →KAKEN DB
Fuji, Hiroshi Browse this author →KAKEN DB
Okumura, Toshiyuki Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Sakurai, Hideyuki Browse this author →KAKEN DB
Keywords: Observational study
Proton beam therapy
Issue Date: Jul-2016
Publisher: Wiley
Journal Title: Cancer medicine
Volume: 5
Issue: 7
Start Page: 1519
End Page: 1525
Publisher DOI: 10.1002/cam4.743
PMID: 27165972
Abstract: Recent progress in the treatment for pediatric malignancies using a combination of surgery, chemotherapy, and radiotherapy has improved survival. However, late toxicities of radiotherapy are a concern in long‐term survivors. A recent study suggested reduced secondary cancer and other late toxicities after proton beam therapy (PBT) due to dosimetric advantages. In this study, we evaluated the safety and efficacy of PBT for pediatric patients treated in Japan. A retrospective observational study in pediatric patients who received PBT was performed. All patients aged <20 years old who underwent PBT from January 1983 to August 2014 at four sites in Japan were enrolled in the study. There were 343 patients in the study. The median follow‐up periods were 22.6 months (0.4–374.3 months) for all patients and 30.6 months (0.6–374.3 months) for survivors. The estimated 1‐, 3‐, 5‐, and 10‐year survival rates were 82.7% (95% CI: 78.5–87.0%), 67.4% (61.7–73.2%), 61.4% (54.8–67.9%), and 58.7% (51.5–65.9%), respectively. Fifty‐two events of toxicity ≥ grade 2 occurred in 43 patients. Grade 4 toxicities of myelitis, visual loss (two cases), cerebral vascular disease, and tissue necrosis occurred in five patients. This study provides preliminary results for PBT in pediatric patients in Japan. More experience and follow‐up with this technique are required to establish the efficacy of PBT in this patient population.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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