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Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay : A retrospective, multi-institutional investigation in Hokkaido, Japan

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Title: Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay : A retrospective, multi-institutional investigation in Hokkaido, Japan
Authors: Fukuda, Atsushi Browse this author
Morita, Shinya Browse this author
Nakamaru, Yuji Browse this author →KAKEN DB
Hoshino, Kimiko Browse this author
Fujiwara, Keishi Browse this author
Akazawa, Shigeru Browse this author
Sakashita, Tomohiro Browse this author →KAKEN DB
Obara, Nobuyuki Browse this author
Homma, Akihiro Browse this author →KAKEN DB
Keywords: Mumps deafness
Asymptomatic mumps
Anti-mumps IgM antibody
Sudden sensorineural hearing loss (SSNHL)
Vaccination
Issue Date: Oct-2018
Publisher: Elsevier
Journal Title: Auris nasus larynx
Volume: 45
Issue: 5
Start Page: 911
End Page: 915
Publisher DOI: 10.1016/j.anl.2017.11.016
Abstract: Objective: Although elevated anti-mumps IgM antibody levels were reported in 5.7%-7.2% of Japanese patients with sudden sensorineural hearing loss (SSNHL), there were several reports of false-positive cases, such as the continually IgM positive case and the IgM positive case in normal adults. To improve specificity, the new enzyme immuno assay (EIA) anti-mumps IgM antibody measurement kit was introduced in December 2009. This study re-examined the frequency of anti mumps IgM antibody test positivity with SSNHL using the new measurement kit and compared the results with those from a previous report that used old kit. Methods: This is a retrospective multi-institutional study involving patients diagnosed with SSNHL who exhibited the anti-mumps IgM antibody. We compared the positive rate of anti-mumps IgM antibody and the annual average number of mumps cases per sentinel in Hokkaido between the patients in the present study and patients previously evaluated. Results: Overall, 100 patients with SSNHL were enrolled. One case (1.0%) was positive for anti mumps IgM antibody. Of the 69 patients evaluated in the previous study, 5 cases (7.2%) were positive for anti-mumps IgM antibody. The positive rate of the anti-mumps IgM antibody in the present cases was significantly lower than that previously reported (p = 0.042). The annual average number of mumps cases per sentinel in Hokkaido of the present and previous surveillance period was 34.47 and 42.77, respectively; no significant difference was seen in these data (p = 0.4519). Conclusion: The present study revealed that 1.0% of SSNHL was positive for the anti-mumps IgM antibody using the new EIA-IgM measurement kit. After the introduction of the new EIA-IgM measurement kit, anti-mumps IgM antibody positive rate with SSNHL significantly decreased, indicating that the proportion of asymptomatic mumps among etiology of SSNHL may be lower than those previously reported.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/75597
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 福田 篤

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