Title: | Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2 : temperance reduces the risk |
Other Titles: | Risk of metachronous SCC |
Authors: | Abiko, Satoshi Browse this author |
Shimizu, Yuichi Browse this author →KAKEN DB |
Miyamoto, Shuichi Browse this author |
Ishikawa, Marin Browse this author |
Matsuda, Kana Browse this author |
Tsuda, Momoko Browse this author |
Mizushima, Takeshi Browse this author |
Yamamoto, Keiko Browse this author |
Ono, Shoko Browse this author |
Kudo, Takahiko Browse this author |
Ono, Kota Browse this author |
Sakamoto, Naoya Browse this author →KAKEN DB |
Keywords: | Alcohol dehydrogenase1B |
Aldehyde dehydrogenase2 |
Squamous cell carcinoma |
Esophageal cancer |
Endoscopic resection |
Issue Date: | Oct-2018 |
Publisher: | Springer |
Journal Title: | Journal of gastroenterology |
Volume: | 53 |
Issue: | 10 |
Start Page: | 1120 |
End Page: | 1130 |
Publisher DOI: | 10.1007/s00535-018-1441-7 |
Abstract: | Background: Metachronous multiple squamous cell carcinoma (SCC) of the esophagus and the head and neck is commonly observed in patients who have previously undergone endoscopic resection (ER) for SCC of the esophagus (ESCC). We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as the alcohol consumption and smoking habits. Methods: We studied 158 patients who underwent ER for ESCC (median follow-up 80 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. The alcohol consumption and smoking histories of the patients before and after the ER were documented. Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. We analyzed 110 patients who had a history of moderate or heavy alcohol consumption before the ER. The 3-year cumulative incidence rates of secondary SCC in the temperance (n = 65) and non-temperance groups (n = 45) were 14.0 and 42.1% (p = 0.0002). Further, the 5-year cumulative incidence rates of a third SCC in the temperance and non-temperance groups were 0 and 15.6% (p = 0.0011), respectively. In addition, the 7-year cumulative incidence rates of a fourth SCC in the temperance and non-temperance groups were 0 and 15.3% (p = 0.0015), respectively. Conclusions: Continued alcohol consumption is an important risk factor for the onset of metachronous SCC and is a risk factor for the third and subsequent SCCs. Strict advice in favor of temperance is crucial. |
Rights: | The final publication is available at link.springer.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/75623 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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