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Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2 : temperance reduces the risk

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Title: Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2 : temperance reduces the risk
Other Titles: Risk of metachronous SCC
Authors: Abiko, Satoshi Browse this author
Shimizu, Yuichi Browse this author →KAKEN DB
Miyamoto, Shuichi Browse this author
Ishikawa, Marin Browse this author
Matsuda, Kana Browse this author
Tsuda, Momoko Browse this author
Mizushima, Takeshi Browse this author
Yamamoto, Keiko Browse this author
Ono, Shoko Browse this author
Kudo, Takahiko Browse this author
Ono, Kota Browse this author
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Alcohol dehydrogenase1B
Aldehyde dehydrogenase2
Squamous cell carcinoma
Esophageal cancer
Endoscopic resection
Issue Date: Oct-2018
Publisher: Springer
Journal Title: Journal of gastroenterology
Volume: 53
Issue: 10
Start Page: 1120
End Page: 1130
Publisher DOI: 10.1007/s00535-018-1441-7
Abstract: Background: Metachronous multiple squamous cell carcinoma (SCC) of the esophagus and the head and neck is commonly observed in patients who have previously undergone endoscopic resection (ER) for SCC of the esophagus (ESCC). We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as the alcohol consumption and smoking habits. Methods: We studied 158 patients who underwent ER for ESCC (median follow-up 80 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. The alcohol consumption and smoking histories of the patients before and after the ER were documented. Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. We analyzed 110 patients who had a history of moderate or heavy alcohol consumption before the ER. The 3-year cumulative incidence rates of secondary SCC in the temperance (n = 65) and non-temperance groups (n = 45) were 14.0 and 42.1% (p = 0.0002). Further, the 5-year cumulative incidence rates of a third SCC in the temperance and non-temperance groups were 0 and 15.6% (p = 0.0011), respectively. In addition, the 7-year cumulative incidence rates of a fourth SCC in the temperance and non-temperance groups were 0 and 15.3% (p = 0.0015), respectively. Conclusions: Continued alcohol consumption is an important risk factor for the onset of metachronous SCC and is a risk factor for the third and subsequent SCCs. Strict advice in favor of temperance is crucial.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/75623
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂本 直哉

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