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An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A

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Title: An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A
Authors: Miura, Ryu Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Miyake, Kunio Browse this author →KAKEN DB
Chen, Mei-Lien Browse this author
Kobayashi, Sumitaka Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Yamamoto, Jun Browse this author
Matsumura, Toru Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Kubota, Takeo Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Issue Date: 26-Aug-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Start Page: 12369
Publisher DOI: 10.1038/s41598-019-48916-5
PMID: 31451752
Abstract: Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially methylated CpGs with p-value < 0.0001 was hypomethylated among all newborns (91%) and female infants (98%), as opposed to being hypermethylated (88%) among males. We found 27 and 16 CpGs with a false discovery rate (FDR) < 0.05 in the analyses for males and females, respectively. Genes annotated to FDR-corrected CpGs clustered into an interconnected genetic network among males, while they rarely exhibited any interactions in females. In contrast, none of the enrichment for gene ontology (GO) terms with FDR < 0.05 was observed for genes annotated to the male-specific CpGs with p < 0.0001, whereas the female-specific genes were significantly enriched for GO terms related to cell adhesion. Our epigenome-wide analysis of cord blood DNA methylation implies potential sex-specific epigenome responses to BPA exposure.
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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