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Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese : the Japan Collaborative Cohort Study

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Title: Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese : the Japan Collaborative Cohort Study
Authors: Nishida, Yoko Browse this author
Kubota, Yasuhiko Browse this author
Iso, Hiroyasu Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Mori, Mitsuru Browse this author
Kaneko, Yoshihiro Browse this author
Tsuji, Ichiro Browse this author
Nakamura, Yosikazu Browse this author
Iso, Hiroyasu Browse this author
Yamagishi, Kazumasa Browse this author
Mikami, Haruo Browse this author
Kurosawa, Michiko Browse this author
Hoshiyama, Yoshiharu Browse this author
Tanabe, Naohito Browse this author
Tamakoshi, Koji Browse this author
Wakai, Kenji Browse this author
Ando, Masahiko Browse this author
Suzuki, Koji Browse this author
Hashimoto, Shuji Browse this author
Yatsuya, Hiroshi Browse this author
Kikuchi, Shogo Browse this author
Wada, Yasuhiko Browse this author
Kawamura, Takashi Browse this author
Watanabe, Yoshiyuki Browse this author
Ozasa, Kotaro Browse this author
Mikami, Kazuya Browse this author
Date, Chigusa Browse this author
Sakata, Kiyomi Browse this author
Kurozawa, Yoichi Browse this author
Fujino, Yoshihisa Browse this author
Shibata, Akira Browse this author
Keywords: Eczema
Cardiovascular disease
Population-based study
Issue Date: 1-Sep-2019
Publisher: Japan Atherosclerosis Society (JAS)
Journal Title: Journal of atherosclerosis and thrombosis
Volume: 26
Issue: 9
Start Page: 775
End Page: 782
Publisher DOI: 10.5551/jat.46383
Abstract: Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who "sometimes" or "often" had eczema had 0.82 (95%confidence interval (CI): 0.69-0.97) or 1.26 (95%CI: 1.01-1.56) times the risk of mortality from CHD, respectively, compared to those who "seldom" did. Individuals who "often" had 1.30 (95%CI: 1.05-1.61) times the risk of mortality from CHD, compared to those who "seldom or sometimes" did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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