| Title: | Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese : the Japan Collaborative Cohort Study |
| Authors: | Nishida, Yoko Browse this author |
| Kubota, Yasuhiko Browse this author |
| Iso, Hiroyasu Browse this author →KAKEN DB |
| Tamakoshi, Akiko Browse this author →KAKEN DB |
| Mori, Mitsuru Browse this author |
| Kaneko, Yoshihiro Browse this author |
| Tsuji, Ichiro Browse this author |
| Nakamura, Yosikazu Browse this author |
| Iso, Hiroyasu Browse this author |
| Yamagishi, Kazumasa Browse this author |
| Mikami, Haruo Browse this author |
| Kurosawa, Michiko Browse this author |
| Hoshiyama, Yoshiharu Browse this author |
| Tanabe, Naohito Browse this author |
| Tamakoshi, Koji Browse this author |
| Wakai, Kenji Browse this author |
| Ando, Masahiko Browse this author |
| Suzuki, Koji Browse this author |
| Hashimoto, Shuji Browse this author |
| Yatsuya, Hiroshi Browse this author |
| Kikuchi, Shogo Browse this author |
| Wada, Yasuhiko Browse this author |
| Kawamura, Takashi Browse this author |
| Watanabe, Yoshiyuki Browse this author |
| Ozasa, Kotaro Browse this author |
| Mikami, Kazuya Browse this author |
| Date, Chigusa Browse this author |
| Sakata, Kiyomi Browse this author |
| Kurozawa, Yoichi Browse this author |
| Fujino, Yoshihisa Browse this author |
| Shibata, Akira Browse this author |
| Keywords: | Eczema |
| Cardiovascular disease |
| Atherosclerosis |
| CHD |
| Population-based study |
| Issue Date: | 1-Sep-2019 |
| Publisher: | Japan Atherosclerosis Society (JAS) |
| Journal Title: | Journal of atherosclerosis and thrombosis |
| Volume: | 26 |
| Issue: | 9 |
| Start Page: | 775 |
| End Page: | 782 |
| Publisher DOI: | 10.5551/jat.46383 |
| Abstract: | Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who "sometimes" or "often" had eczema had 0.82 (95%confidence interval (CI): 0.69-0.97) or 1.26 (95%CI: 1.01-1.56) times the risk of mortality from CHD, respectively, compared to those who "seldom" did. Individuals who "often" had 1.30 (95%CI: 1.05-1.61) times the risk of mortality from CHD, compared to those who "seldom or sometimes" did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75845 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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