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Carbapenem-resistant Pseudomonas aeruginosa and carbapenem use in Japan: an ecological study

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Title: Carbapenem-resistant Pseudomonas aeruginosa and carbapenem use in Japan: an ecological study
Authors: Terahara, Fumitaka Browse this author
Nishiura, Hiroshi Browse this author →KAKEN DB
Keywords: Antibiotic resistance
Pseudomonas aeruginosa
carbapenem
drug prescription
epidemiology
antimicrobial stewardship
Issue Date: Oct-2019
Publisher: SAGE Publications
Journal Title: Journal of international medical research
Volume: 47
Issue: 10
Start Page: 4711
End Page: 4722
Publisher DOI: 10.1177/0300060519864181
PMID: 31366256
Abstract: Objective This study focused on carbapenem resistance in Pseudomonas aeruginosa and examined potential ecological correlations with carbapenem use in Japan. Methods The proportion of carbapenem-resistant P. aeruginosa isolates from 2015 and 2016 by prefecture was obtained from the Japan Nosocomial Infections Surveillance system. Data on carbapenem use was obtained from the National Database of Health Insurance Claims. The correlation between the proportion of carbapenem-resistant isolates and carbapenem consumption was assessed in a cross-sectional manner. The study also collected information on other variables including the numbers of physicians, nurses and medical facilities per 100 000 individuals by prefecture. Results Both the proportion of carbapenem-resistant P. aeruginosa isolates and levels of carbapenem use were higher in western Japan. Using a multivariate model, only carbapenem use remained significantly associated with the proportion of carbapenem-resistant isolates. Conclusions Carbapenem use and the proportion of carbapenem-resistant P. aeruginosa isolates were positively correlated. By longitudinal data collection, this approach offers an avenue to establish causal links as the frequency of carbapenem-resistant P. aeruginosa isolates starts to change in the future.
Rights: https://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/75846
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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