| Title: | Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma |
| Authors: | Nisa, Khoirun Browse this author |
| Lim, Sue Yee Browse this author |
| Shinohara, Masayoshi Browse this author |
| Osuga, Tatsuyuki Browse this author |
| Yokoyama, Nozomu Browse this author |
| Tamura, Masahiro Browse this author |
| Nagata, Noriyuki Browse this author |
| Sasaoka, Kazuyoshi Browse this author |
| Dermlim, Angkhana Browse this author |
| Leela-Arporn, Rommaneeya Browse this author |
| Morita, Tomoya Browse this author |
| Sasaki, Noboru Browse this author →KAKEN DB |
| Morishita, Keitaro Browse this author →KAKEN DB |
| Nakamura, Kensuke Browse this author →KAKEN DB |
| Ohta, Hiroshi Browse this author →KAKEN DB |
| Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
| Keywords: | CEUS |
| enhancement |
| intestinal diseases |
| tissue perfusion |
| Issue Date: | Mar-2019 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Veterinary Internal Medicine |
| Volume: | 33 |
| Issue: | 2 |
| Start Page: | 559 |
| End Page: | 568 |
| Publisher DOI: | 10.1111/jvim.15432 |
| Abstract: | Background: Contrast-enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease in humans and could be useful for dogs with chronic intestinal diseases. Objectives: To examine duodenal perfusion in dogs with chronic inflammatory enteropathy (CIE) and intestinal lymphoma. Animals: Client-owned dogs with CIE (n = 26) or intestinal lymphoma (n = 7) and dogs with gastrointestinal signs but histopathologically normal duodenum (controls, n = 14). Methods: In this cross-sectional study, clogs with CIE were classified into remission (n = 16) and symptomatic (n = 10) groups based on clinical scores determined at the time of CEUS. The duodenum was scanned after IV injection of Sonazoid (R) (0.01 mL/kg). CEUS-derived perfusion parameters, including time-to-peak, peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates were evaluated. Results: The PI was significantly higher in the symptomatic CIE group (median (range); 105.4 (89.3-128.8) MPV) than in the control group (89.9 (68.5-112.2) MPV). The AUC was significantly higher in the symptomatic CIE group (4847.9 (3824.3-8462.8) MPV.sec) than in the control (3448.9 (1559.5-4736.9) MPV.sec) and remission CIE (3862.3 (2094.5-6899.0) MPV.sec) groups. The PI and clinical score were positively correlated in the CIE group. No significant differences in perfusion parameters were detected between the lymphoma and CIE groups or the lymphoma and control groups. Conclusions and Clinical Importance: The PI and AUC can detect duodenal inflammation and hence are potentially useful for excluding a diagnosis of CIE. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75895 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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