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Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma

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Title: Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma
Authors: Nisa, Khoirun Browse this author
Lim, Sue Yee Browse this author
Shinohara, Masayoshi Browse this author
Osuga, Tatsuyuki Browse this author
Yokoyama, Nozomu Browse this author
Tamura, Masahiro Browse this author
Nagata, Noriyuki Browse this author
Sasaoka, Kazuyoshi Browse this author
Dermlim, Angkhana Browse this author
Leela-Arporn, Rommaneeya Browse this author
Morita, Tomoya Browse this author
Sasaki, Noboru Browse this author →KAKEN DB
Morishita, Keitaro Browse this author →KAKEN DB
Nakamura, Kensuke Browse this author →KAKEN DB
Ohta, Hiroshi Browse this author →KAKEN DB
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: CEUS
enhancement
intestinal diseases
tissue perfusion
Issue Date: Mar-2019
Publisher: John Wiley & Sons
Journal Title: Journal of Veterinary Internal Medicine
Volume: 33
Issue: 2
Start Page: 559
End Page: 568
Publisher DOI: 10.1111/jvim.15432
Abstract: Background: Contrast-enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease in humans and could be useful for dogs with chronic intestinal diseases. Objectives: To examine duodenal perfusion in dogs with chronic inflammatory enteropathy (CIE) and intestinal lymphoma. Animals: Client-owned dogs with CIE (n = 26) or intestinal lymphoma (n = 7) and dogs with gastrointestinal signs but histopathologically normal duodenum (controls, n = 14). Methods: In this cross-sectional study, clogs with CIE were classified into remission (n = 16) and symptomatic (n = 10) groups based on clinical scores determined at the time of CEUS. The duodenum was scanned after IV injection of Sonazoid (R) (0.01 mL/kg). CEUS-derived perfusion parameters, including time-to-peak, peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates were evaluated. Results: The PI was significantly higher in the symptomatic CIE group (median (range); 105.4 (89.3-128.8) MPV) than in the control group (89.9 (68.5-112.2) MPV). The AUC was significantly higher in the symptomatic CIE group (4847.9 (3824.3-8462.8) MPV.sec) than in the control (3448.9 (1559.5-4736.9) MPV.sec) and remission CIE (3862.3 (2094.5-6899.0) MPV.sec) groups. The PI and clinical score were positively correlated in the CIE group. No significant differences in perfusion parameters were detected between the lymphoma and CIE groups or the lymphoma and control groups. Conclusions and Clinical Importance: The PI and AUC can detect duodenal inflammation and hence are potentially useful for excluding a diagnosis of CIE.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/75895
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 滝口 満喜

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