| Title: | Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia : A Hokkaido Leukemia Net Study |
| Authors: | Hidaka, Daisuke Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Hashiguchi, Junichi Browse this author |
| Miyashita, Naohiro Browse this author |
| Kasahara, Kohei Browse this author |
| Fujisawa, Shinichi Browse this author |
| Hayase, Eiko Browse this author |
| Okada, Kohei Browse this author |
| Shiratori, Souichi Browse this author →KAKEN DB |
| Goto, Hideki Browse this author |
| Sugita, Junichi Browse this author |
| Nakagawa, Masao Browse this author |
| Hashimoto, Daigo Browse this author |
| Kahata, Kaoru Browse this author |
| Endo, Tomoyuki Browse this author |
| Yamamoto, Satoshi Browse this author |
| Tsutsumi, Yutaka Browse this author |
| Haseyama, Yoshihito Browse this author |
| Nagashima, Takahiro Browse this author |
| Mori, Akio Browse this author |
| Ota, Shuichi Browse this author |
| Sakai, Hajime Browse this author |
| Ishihara, Toshimichi Browse this author |
| Imai, Kiyotoshi Browse this author |
| Miyagishima, Takuto Browse this author |
| Kakinoki, Yasutaka Browse this author |
| Kurosawa, Mitsutoshi Browse this author |
| Kobayashi, Hajime Browse this author |
| Iwasaki, Hiroshi Browse this author |
| Shimizu, Chikara Browse this author →KAKEN DB |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | WT1 |
| prognostic stratification |
| AML |
| Hokkaido Leukemia Net (HLN) |
| North Japan Hematology Study Group (NJHSG) |
| SNP |
| Issue Date: | Nov-2018 |
| Publisher: | Elsevier |
| Journal Title: | Clinical Lymphoma, Myeloma and Leukemia |
| Volume: | 18 |
| Issue: | 11 |
| Start Page: | e469 |
| End Page: | e479 |
| Publisher DOI: | 10.1016/j.clml.2018.07.291 |
| Abstract: | The association between Wilms tumor 1 (WT1) expression, genetic abnormalities and homozygous single polymorphism (SNP) in WT1 gene was evaluated in 252 acute myelogenous leukemia (AML) patients. WT1 expression correlated with prognostic genetic abnormalities. Homozygous WT1 SNP rs16754 was associated with lower expression of WT1. WT1 expression had no prognostic impact in any cytogenetic group or SNP status. Background: The prognostic impact of WT1 expression at diagnosis of acute myelogenous leukemia (AML) has been controversial. The aim of this study was to determine the correlations of WT1 expression at diagnosis of AML with established prognostic alterations. Patients and Methods: We analyzed diagnostic bone marrow samples from 252 patients. WT1 expression, SNP in WT1 gene (rs16754), and Flt3-ITD mutation were analyzed for all patients. NPM1 mutation and CEBPA double mutation were analyzed for cytogenetically normal (CN)-AML. KIT mutation was analyzed for core-binding factor (CBF)-AML. Results: Within the cytogenetically favorable prognosis group, WT1 expression in AML with inv(16) or t(15;17) was significantly higher than that in AML with t(8;21). In cases with CN-AML, Flt3-ITD and NPM1 mutations were both correlated with higher expression of WT1, whereas CEBPA double mutation was related to lower WT1 expression. The existence of both Flt3- ITD and NPM1 mutations showed synergistically higher expression of WT1 in CN-AML. SNP in WT1 gene (rs16754) was significantly associated with lower expression of WT1. WT1 levels were not prognostic factors in the total cohort, in any cytogenetic group nor SNP status. Conclusion: Since WT1 expression correlated to known prognostic factors, the prognostic impact of WT1 levels might be misunderstood depending on the distribution of collaborative mutations in each cohort. We conclude that the prognostic significance of WT1 at diagnosis of AML is weak compared to other established prognostic factors. |
| Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/75971 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
