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Quantitation of sevoflurane in whole blood and aqueous solutions by volatile organic compound sensing

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Title: Quantitation of sevoflurane in whole blood and aqueous solutions by volatile organic compound sensing
Authors: Hase, Yuri Browse this author
Suzuki, Kuniaki Browse this author →KAKEN DB
Kamekura, Nobuhito Browse this author
Shibuya, Makiko Browse this author
Takahashi, Yu Browse this author
Namba, Kosuke Browse this author →KAKEN DB
Fujisawa, Toshiaki Browse this author →KAKEN DB
Keywords: Anesthetic
F-19 NMR
Methods
Quantitation
Sevoflurane
VOC sensor
Issue Date: Nov-2018
Publisher: Elsevier
Journal Title: Journal of pharmacological and toxicological methods
Volume: 94
Start Page: 71
End Page: 76
Publisher DOI: 10.1016/j.vascn.2018.05.005
Abstract: Introduction: It is difficult to quantify poorly soluble volatile anesthetics in aqueous solutions; this necessitates the development of alternative prompt methods to analyze the in vivo blood concentrations of anesthetics for the clinical assessment of anesthesia depth. In this study, we demonstrated that the difficulties can be overcome by using volatile organic compound (VOC) sensors, which allow the levels of vaporized VOCs to be quantified in several seconds and obviate the need for conventional techniques such as gas chromatography or nuclear magnetic resonance (NMR). Methods: The concentrations of a volatile general anesthetic (sevoflurane) in aqueous solutions containing human blood components and rabbit blood were measured using a VOC sensor and those in distilled water and phosphatidylcholine suspension were compared to those determined by NMR. Results: For all aqueous solutions with concentrations of up to 5 mM, the relationship between the VOC content and sevoflurane concentration was represented by a straight line passing through the origin. The concentration of sevoflurane determined by VOC sensing was well correlated with the values obtained by NMR at <1 mM, which is within the clinically relevant concentration levels. Discussion: Considering the results from this study, we can conclude that VOC sensing may be useful for measuring intraoperative blood anesthetic concentrations.
Rights: © <2018>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/75977
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長谷 由理

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