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Selective distribution of GLUT3-expressing nerve fibers in the lamina terminails among the circumventricular organs of mice

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Title: Selective distribution of GLUT3-expressing nerve fibers in the lamina terminails among the circumventricular organs of mice
Authors: Iwanaga, Toshihiko Browse this author →KAKEN DB
Konno, Kohtarou Browse this author →KAKEN DB
Watanabe, Masahiko Browse this author →KAKEN DB
Issue Date: 6-Nov-2019
Publisher: Biomedical Research Press
Journal Title: Biomedical Research (Tokyo)
Volume: 40
Issue: 5
Start Page: 207
End Page: 214
Publisher DOI: 10.2220/biomedres.40.207
Abstract: Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ formed into thin bundles and extended ventro-rostrally over the anterior commissure. After turning over the commissure, the neural tract passed through the median preoptic nucleus (MnPO) and reached the OVLT; thus, a continuous neural tract expressing GLUT3 connected the subfornical organ, MnPO, and OVLT in the lamina terminalis. In the OVLT, GLUT3-immunoreactive fibers gathered in both the dorsal cap and lateral periventricular zone. Electron microscopically, the immunoreactive structures in the subfornical organ corresponded to nerve fibers or nerve terminals containing many small clear vesicles. The area postrema, another sensory organ, was immunonegative for GLUT3. This study not only presented a useful marker tracing the neural tract in the sensory sites of the lamina terminalis but also suggested a unique system for sensing and determining the metabolism of circulating glucose in the circumventricular organs.
Type: article
URI: http://hdl.handle.net/2115/76045
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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