| Title: | Novel echocardiographic method to assess left ventricular chamber stiffness and elevated end-diastolic pressure based on time-velocity integral measurements of pulmonary venous and transmitral flows |
| Authors: | Okada, Kazunori Browse this author |
| Kaga, Sanae Browse this author |
| Abiko, Rika Browse this author |
| Murayama, Michito Browse this author |
| Hioka, Takuma Browse this author |
| Nakabachi, Masahiro Browse this author |
| Yokoyama, Shinobu Browse this author |
| Nishino, Hisao Browse this author |
| Ichikawa, Ayako Browse this author |
| Abe, Ayumu Browse this author |
| Nishida, Mutsumi Browse this author →KAKEN DB |
| Asakawa, Naoya Browse this author |
| Tsujinaga, Shingo Browse this author |
| Hayashi, Taichi Browse this author |
| Iwano, Hiroyuki Browse this author |
| Yamada, Satoshi Browse this author →KAKEN DB |
| Masauzi, Nobuo Browse this author |
| Mikami, Taisei Browse this author →KAKEN DB |
| Keywords: | left ventricular chamber stiffness |
| left ventricular end-diastolic pressure |
| pulmonary venous flow |
| heart failure |
| Issue Date: | 8-Nov-2017 |
| Publisher: | Oxford University Press |
| Journal Title: | European heart journal cardiovascular Imaging |
| Volume: | 19 |
| Issue: | 11 |
| Start Page: | 1260 |
| End Page: | 1267 |
| Publisher DOI: | 10.1093/ehjci/jex305 |
| PMID: | 29228231 |
| Abstract: | Aims The detection of increased left ventricular (LV) chamber stiffness may play an important role in assessing cardiac patients with potential but not overt heart failure. A non-invasive method to estimate it is not established. We investigated whether the echocardiographic backward/forward flow volume ratio from the left atrium (LA) during atrial contraction reflects the LV chamber stiffness. Methods and results We studied 62 patients who underwent cardiac catheterization and measured their left ventricular end-diastolic pressure (LVEDP) and pressure increase during atrial contraction (Delta Pa) from the LV pressure waveform. Using the echocardiographic biplane method of disks, we measured the LV volume change during atrial contraction indexed to the body surface area (Delta Va), and Delta Pa/Delta Va was calculated as a standard for the LV operating chamber stiffness. Using pulsed Doppler echocardiography, we measured the time-velocity integral (TVI) of the backward pulmonary venous (PV) flow during atrial contraction (I-PVA) and the ratio of I-PVA to the PV flow TVI throughout a cardiac cycle (F-PVA). We also measured the TVI of the atrial systolic forward transmitral flow (I-A) and the ratio of the I-A to the transmitral TVI during a cardiac cycle (F-A) and calculated I-PVA/I-A and F-PVA/F-A. IPVA/IA and F-PVA/F-A were well correlated with Delta Pa/Delta Va (r = 0.79 and r = 0.81) and LVEDP (r = 0.73 and r = 0.77). The areas under the ROC curve to discriminate LVEDP > 18mmHg were 0.90 for I-PVA/I-A and 0.93 for F-PVA/F-A. Conclusion The F-PVA/F-A, the backward/forward flow volume ratio from the LA during atrial contraction, is useful for noninvasive assessments of LV chamber stiffness and elevated LVEDP. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in European heart journal cardiovascular imaging following peer review. The version of record Eur J Echocardiogr (2018) 19(11): 1260-1267 is available online at: https://academic.oup.com/ehjcimaging/article/19/11/1260/4710343 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/76080 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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