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Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study
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| Title: | Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study |
| Authors: | Sarathkumara, Yomani D. Browse this author | | Gamage, Chandika D. Browse this author | | Lokupathirage, Sithumini Browse this author | | Muthusinghe, Devinda S. Browse this author | | Nanayakkara, Nishantha Browse this author | | Gunarathne, Lishanthe Browse this author | | Shimizu, Kenta Browse this author →KAKEN DB | | Tsuda, Yoshimi Browse this author | | Arikawa, Jiro Browse this author →KAKEN DB | | Yoshimatsu, Kumiko Browse this author →KAKEN DB |
| Keywords: | Thailand orthohantavirus | | tropical nephropathy | | rodent |
| Issue Date: | Aug-2019 |
| Publisher: | MDPI |
| Journal Title: | Viruses-Basel |
| Volume: | 11 |
| Issue: | 8 |
| Start Page: | 700 |
| Publisher DOI: | 10.3390/v11080700 |
| Abstract: | Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants' demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76131 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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