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Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study

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Title: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study
Authors: Sarathkumara, Yomani D. Browse this author
Gamage, Chandika D. Browse this author
Lokupathirage, Sithumini Browse this author
Muthusinghe, Devinda S. Browse this author
Nanayakkara, Nishantha Browse this author
Gunarathne, Lishanthe Browse this author
Shimizu, Kenta Browse this author →KAKEN DB
Tsuda, Yoshimi Browse this author
Arikawa, Jiro Browse this author →KAKEN DB
Yoshimatsu, Kumiko Browse this author →KAKEN DB
Keywords: Thailand orthohantavirus
tropical nephropathy
Issue Date: Aug-2019
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 11
Issue: 8
Start Page: 700
Publisher DOI: 10.3390/v11080700
Abstract: Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants' demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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