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Plasma amino acid profiles in dogs with inflammatory bowel disease

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Title: Plasma amino acid profiles in dogs with inflammatory bowel disease
Authors: Tamura, Yu Browse this author
Ohta, Hiroshi Browse this author
Kagawa, Yumiko Browse this author
Osuga, Tatsuyuki Browse this author
Morishita, Keitaro Browse this author
Sasaki, Noboru Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: canine
chronic enteropathy
gastrointestinal disease
metabolism
Issue Date: Jul-2019
Publisher: John Wiley & Sons
Journal Title: Journal of Veterinary Internal Medicine
Volume: 33
Issue: 4
Start Page: 1602
End Page: 1607
Publisher DOI: 10.1111/jvim.15525
Abstract: Background Lymphocytic-plasmacytic enteritis is the common form of idiopathic inflammatory bowel disease (IBD) in dogs. In human IBD, disturbances of amino acid metabolism have been demonstrated to be involved in the pathophysiology of IBD. Therefore, plasma amino acid profile might represent a novel marker of human IBD. Objectives To determine the plasma amino acid profiles of dogs with IBD and its usefulness as a novel marker of IBD in dogs. Animals Fasting blood plasma was obtained from 10 dogs with IBD and 12 healthy dogs. Methods All IBD dogs were prospectively included in this study, and heparinized blood samples were collected. The plasma concentrations of 21 amino acids were determined using the ninhydrin method. The relationships among the plasma amino acid concentrations and plasma C-reactive protein (CRP) concentration, canine chronic enteropathy clinical activity index (CCECAI), and overall World Small Animal Veterinary Association (WSAVA) score were investigated. Results Median concentration (nmol/mL) of methionine [46.2; range, 30.0-59.3], proline [119.4; range, 76.7-189.2], serine [115.1; range, 61.4-155.9], and tryptophan [17.4; range, 11.9-56.3]) were significantly lower than in control dogs [62.6; range, 51.0-83.6, 199.1; range, 132.5-376.7, 164.3; range, 124.7-222.9, and 68.3; range, 35.7-94.8, respectively]. A negative correlation was identified between the plasma serine concentration and CCECAI (r(s) = -.67, P = .03), but there were no correlations between plasma amino acid concentrations and CRP concentration or overall WSAVA score. Conclusions and Clinical Importance Plasma serine concentration might represent a novel maker of IBD in dogs.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/76134
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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