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Plasma-free amino acid profiles in dogs with hepatocellular carcinoma

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Title: Plasma-free amino acid profiles in dogs with hepatocellular carcinoma
Authors: Leela-arporn, Rommaneeya Browse this author
Ohta, Hiroshi Browse this author
Tamura, Masahiro Browse this author
Nagata, Noriyuki Browse this author
Sasaoka, Kazuyoshi Browse this author
Dermlim, Angkhana Browse this author
Nisa, Khoirun Browse this author
Osuga, Tatsuyuki Browse this author
Morishita, Keitaro Browse this author
Sasaki, Noboru Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: biomarker
dog
liver tumor
metabolomics
Issue Date: Jul-2019
Publisher: John Wiley & Sons
Journal Title: Journal of Veterinary Internal Medicine
Volume: 33
Issue: 4
Start Page: 1653
End Page: 1659
Publisher DOI: 10.1111/jvim.15512
Abstract: Background Metabolomic analysis using blood samples has been suggested to be useful for the early detection of cancer. Among metabolites, plasma-free amino acid (PFAA) profiles are potential diagnostic biomarkers for several diseases including cancer. However, the relationship between PFAA concentrations and liver tumors in dogs remains unknown. Objective To determine the characteristics of PFAA profiles of dogs with hepatocellular carcinoma (HCC) and correlated clinical features. Animals Thirty-four client-owned dogs diagnosed with HCC (n = 26) and benign liver diseases (n = 8) and 11 age-matched healthy dogs. Methods Prospective study using heparinized blood samples from fasted dogs. Plasma was deproteinized, and the concentrations of 21 amino acids were measured using an automated high-performance liquid chromatography amino acid analyzer. Results Plasma glutamic acid concentrations were significantly different among groups (P < .0024 after Bonferroni correction). Compared to healthy dogs, dogs with HCC and benign liver diseases had significantly higher concentrations of glutamic acid by post hoc analysis. However, no significant difference in the PFAA profiles of HCC and benign liver diseases were detected. In addition, preoperative and postoperative PFAA profiles of dogs with HCC were not significantly different. Conclusions and Clinical Importance Increased glutamic acid concentrations might play a role in the development or be a consequence of liver tumor formation. However, PFAA profiles of HCC could not be differentiated from those of benign lesions. In addition, glutamic acid concentrations did not change after surgical resection. These results indicate that PFAA profiles may not be useful biomarkers for detecting HCC in dogs.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/76135
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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