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Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease

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Title: Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease
Authors: Tamura, Masahiro Browse this author
Ohta, Hiroshi Browse this author
Shimbo, Genya Browse this author
Osuga, Tatsuyuki Browse this author
Sasaki, Noboru Browse this author
Morishita, Keitaro Browse this author
Kagawa, Yumiko Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: 2D-SWE
canine
liver biopsy
liver disease
SWV
Issue Date: 15-Nov-2019
Publisher: John Wiley & Sons
Journal Title: Journal of Veterinary Internal Medicine
Publisher DOI: 10.1111/jvim.15598
Abstract: Background Two-dimensional shear wave elastography (2D-SWE) can noninvasively evaluate hepatic elastic modulus as shear wave velocity (SWV). Additionally, it may predict the presence of clinical relevant hepatic fibrosis (>= F2) in dogs with hepatic disease. Objectives To investigate whether SWV measured by 2D-SWE can differentiate between dogs with (>= F2) and without (F0-1) clinically relevant hepatic fibrosis. Animals Twenty-eight client-owned dogs with hepatic disease and 8 normal healthy Beagle dogs were enrolled. Methods In this cross-sectional prospective study, SWVs were measured using 2D-SWE in all dogs. Hepatic fibrosis stages and necroinflammatory activity grades were histopathologically evaluated using a histological scoring scheme that was adapted from the Ishak schema used in human medicine. Results Median SWVs were significantly higher in dogs with clinically relevant hepatic fibrosis (2.04 m/s; range, 1.81-2.26 m/s) than in healthy dogs (1.51 m/s; range, 1.44-1.66 m/s; P = .007), and dogs without clinically relevant hepatic fibrosis (1.56 m/s; range, 1.37-1.67 m/s; P < .001). However, no significant difference was found in the SWVs between dogs without clinically relevant hepatic fibrosis and healthy dogs (P = .99). Furthermore, median SWVs were not significantly different among dogs with necroinflammatory activity, those without necroinflammatory activity, and healthy dogs (Kruskal-Wallis test, P = .12). Conclusions and Clinical Importance The 2D-SWE may be useful for predicting the presence of hepatic fibrosis in dogs with hepatic disease.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/76139
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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