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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease
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| Title: | Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease |
| Authors: | Tamura, Masahiro Browse this author | | Ohta, Hiroshi Browse this author | | Shimbo, Genya Browse this author | | Osuga, Tatsuyuki Browse this author | | Sasaki, Noboru Browse this author | | Morishita, Keitaro Browse this author | | Kagawa, Yumiko Browse this author | | Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
| Keywords: | 2D-SWE | | canine | | liver biopsy | | liver disease | | SWV |
| Issue Date: | 28-Aug-2019 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Veterinary Internal Medicine |
| Volume: | 33 |
| Issue: | 5 |
| Start Page: | 2067 |
| End Page: | 2074 |
| Publisher DOI: | 10.1111/jvim.15598 |
| Abstract: | Background Two-dimensional shear wave elastography (2D-SWE) can noninvasively evaluate hepatic elastic modulus as shear wave velocity (SWV). Additionally, it may predict the presence of clinical relevant hepatic fibrosis (>= F2) in dogs with hepatic disease. Objectives To investigate whether SWV measured by 2D-SWE can differentiate between dogs with (>= F2) and without (F0-1) clinically relevant hepatic fibrosis. Animals Twenty-eight client-owned dogs with hepatic disease and 8 normal healthy Beagle dogs were enrolled. Methods In this cross-sectional prospective study, SWVs were measured using 2D-SWE in all dogs. Hepatic fibrosis stages and necroinflammatory activity grades were histopathologically evaluated using a histological scoring scheme that was adapted from the Ishak schema used in human medicine. Results Median SWVs were significantly higher in dogs with clinically relevant hepatic fibrosis (2.04 m/s; range, 1.81-2.26 m/s) than in healthy dogs (1.51 m/s; range, 1.44-1.66 m/s; P = .007), and dogs without clinically relevant hepatic fibrosis (1.56 m/s; range, 1.37-1.67 m/s; P < .001). However, no significant difference was found in the SWVs between dogs without clinically relevant hepatic fibrosis and healthy dogs (P = .99). Furthermore, median SWVs were not significantly different among dogs with necroinflammatory activity, those without necroinflammatory activity, and healthy dogs (Kruskal-Wallis test, P = .12). Conclusions and Clinical Importance The 2D-SWE may be useful for predicting the presence of hepatic fibrosis in dogs with hepatic disease. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76139 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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