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Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients

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Title: Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients
Authors: Shirakawa, Ryosuke Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Nakajima, Takayuki Browse this author
Takada, Shingo Browse this author →KAKEN DB
Yamane, Miwako Browse this author
Furihata, Takaaki Browse this author →KAKEN DB
Maekawa, Satoshi Browse this author
Nambu, Hideo Browse this author
Katayama, Takashi Browse this author
Fukushima, Arata Browse this author →KAKEN DB
Saito, Akimichi Browse this author
Ishimori, Naoki Browse this author →KAKEN DB
Dela, Flemming Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Anzai, Toshihisa Browse this author →KAKEN DB
Issue Date: 11-Oct-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Start Page: 14709
Publisher DOI: 10.1038/s41598-019-51298-3
Abstract: Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxygen species (ROS) generation in circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total of 31 patients who had a history of hospital admission due to worsening HF were enrolled and grouped as having either mild CHF defined as NewYork Heart Association (NYHA) functional class I-II or moderate-to-severe CHF defined as NYHA functional class III. ROS levels in PBMC mitochondria were significantly increased in CHF patients with NYHA functional class III compared to those with NYHA functional class I-II, accompanied by impaired mitochondrial respiratory capacity in PBMCs. ROS generation in PBMC mitochondria was positively correlated with urinary 8-hydroxydeoxyguanosine, a systemic oxidative stress marker, in CHF patients. Importantly, mitochondrial ROS generation in PBMCs was directly correlated with plasma levels of B-type natriuretic peptide, a biomarker for severity of HF, and inversely correlated with peak oxygen uptake, a parameter of exercise capacity, in CHF patients. The study showed that ROS generation in PBMC mitochondria was higher in patients with advanced CHF, and it was associated with disease severity and exercise intolerance in CHF patients.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/76189
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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