| Title: | Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients |
| Authors: | Shirakawa, Ryosuke Browse this author |
| Yokota, Takashi Browse this author →KAKEN DB |
| Nakajima, Takayuki Browse this author |
| Takada, Shingo Browse this author →KAKEN DB |
| Yamane, Miwako Browse this author |
| Furihata, Takaaki Browse this author →KAKEN DB |
| Maekawa, Satoshi Browse this author |
| Nambu, Hideo Browse this author |
| Katayama, Takashi Browse this author |
| Fukushima, Arata Browse this author →KAKEN DB |
| Saito, Akimichi Browse this author |
| Ishimori, Naoki Browse this author →KAKEN DB |
| Dela, Flemming Browse this author |
| Kinugawa, Shintaro Browse this author →KAKEN DB |
| Anzai, Toshihisa Browse this author →KAKEN DB |
| Issue Date: | 11-Oct-2019 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 9 |
| Start Page: | 14709 |
| Publisher DOI: | 10.1038/s41598-019-51298-3 |
| Abstract: | Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxygen species (ROS) generation in circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total of 31 patients who had a history of hospital admission due to worsening HF were enrolled and grouped as having either mild CHF defined as NewYork Heart Association (NYHA) functional class I-II or moderate-to-severe CHF defined as NYHA functional class III. ROS levels in PBMC mitochondria were significantly increased in CHF patients with NYHA functional class III compared to those with NYHA functional class I-II, accompanied by impaired mitochondrial respiratory capacity in PBMCs. ROS generation in PBMC mitochondria was positively correlated with urinary 8-hydroxydeoxyguanosine, a systemic oxidative stress marker, in CHF patients. Importantly, mitochondrial ROS generation in PBMCs was directly correlated with plasma levels of B-type natriuretic peptide, a biomarker for severity of HF, and inversely correlated with peak oxygen uptake, a parameter of exercise capacity, in CHF patients. The study showed that ROS generation in PBMC mitochondria was higher in patients with advanced CHF, and it was associated with disease severity and exercise intolerance in CHF patients. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76189 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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