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Anti-PcrV titers in non-cystic fibrosis patients with Pseudomonas aeruginosa respiratory tract infection

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Title: Anti-PcrV titers in non-cystic fibrosis patients with Pseudomonas aeruginosa respiratory tract infection
Authors: Nagaoka, Kentaro Browse this author
Yamashita, Yu Browse this author
Kimura, Hirokazu Browse this author
Kimura, Hiroki Browse this author →KAKEN DB
Suzuki, Masaru Browse this author →KAKEN DB
Fukumoto, Tatsuya Browse this author
Hayasaka, Kasumi Browse this author
Yoshida, Mari Browse this author
Hara, Takafumi Browse this author
Maki, Hideki Browse this author
Ohkawa, Tomoyuki Browse this author
Konno, Satoshi Browse this author →KAKEN DB
Keywords: Pseudomonas aeruginosa
Pneumonia
Anti-PcrV antibody
Colonization
Issue Date: Oct-2019
Publisher: Elsevier
Journal Title: International journal of infectious diseases
Volume: 87
Start Page: 54
End Page: 59
Publisher DOI: 10.1016/j.ijid.2019.08.008
Abstract: Objective: The epidemiology and role of the anti-PcrV titer in non-cystic fibrosis patients with Pseudomonas aeruginosa airway tract infections is not fully understood. This study was performed to compare the anti-PcrV titers of patients with and without P. aeruginosa respiratory tract infections. Methods: This prospective cohort study was conducted at Hokkaido University Hospital in Japan. Participants had blood and sputum specimens collected on admission. They were divided into two groups based on their sputum culture results. Those with a P. aeruginosa infection were assigned to the P. aeruginosa (PA) group and those without a P. aeruginosa infection were assigned to the non-PA group. Serum anti-PcrV titers were measured using a validated ELISA. Results: Of the 44 participants, 15 were assigned to the PA group and 29 were assigned to the non-PA group. In the PA group, 10/15 participants (66.7%) had an anti-PcrV titer >1000 ng/ml compared to 3/29 participants (10.3%) in the non-PA group (p < 0.001). In the PA group, two of the five participants with an anti-PcrV titer <1000 ng/ml died of recurrent P. aeruginosa pneumonia; the other three participants did not develop pneumonia. Conclusion: The anti-PcrV titers in participants with P. aeruginosa infection varied considerably. Patients with low anti-PcrV titers and refractory P. aeruginosa infections need to be monitored closely. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/76192
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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