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Volume 67 Number 4 >

Molecular characterization of a virulent strain of Newcastle disease virus isolated from a diseased chicken in Kyrgyzstan in 2016

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Title: Molecular characterization of a virulent strain of Newcastle disease virus isolated from a diseased chicken in Kyrgyzstan in 2016
Authors: Thi Huong, Giang Tran Browse this author
Van, Hieu Dong Browse this author
Duy, Tung Dao Browse this author
Iskender, Saadanov Browse this author
Mairambek, Isakeev Browse this author
Omatsu, Tsutomu Browse this author →KAKEN DB
Katayama, Yukie Browse this author
Mizutani, Tetsuya Browse this author →KAKEN DB
Ozeki, Yuki Browse this author
Takeda, Yohei Browse this author →KAKEN DB
Ogawa, Haruko Browse this author →KAKEN DB
Imai, Kunitoshi Browse this author →KAKEN DB
Keywords: Kyrgyzstan
Newcastle disease
Genome characterization
Issue Date: Nov-2019
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 67
Issue: 4
Start Page: 263
End Page: 273
Abstract: Newcastle disease (ND) is a contagious viral disease affecting birds throughout the world and causing economic losses in the poultry industry. At present, little is known about the genetic causes of the ND outbreak that occurred in commercial poultry farms in Kyrgyzstan in 2016. In the current study, we isolated and confirmed a strain of ND virus (NDV) isolated from one out of two samples obtained from an unvaccinated flock. Based on phylogenetic analyses, this NDV strain was clustered in the class II subgenotype VIId and was closely related to the Chinese NDV isolate. Phylogenetic analyses also revealed that the isolated NDV strain has an origin different from the four NDV strains previously identified in Kyrgyzstan. According to a multibasic amino acid (aa) sequence at the F0 proteolytic cleavage site (112R-R-Q-K-R-F117), the NDV isolate was determined as a virulent strain. Several mutations in the neutralizing epitopes (notably, E347→K) and the global head were observed in the hemagglutininneuraminidase protein of the new isolate. The present study represents the first molecular characterization of the coding region of NDV genome obtained from Kyrgyzstan in 2016. This essential information may be useful for ND diagnostics and control.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 67 Number 4

Submitter: 獣医学部図書室

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