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Volume 67 Number 4 >

Evaluation of myocardial protective effects of enalapril maleate against experimental supraventricular tachyarrhythmia in dogs by measuring cardiac troponin I levels

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.67.4.281

Title: Evaluation of myocardial protective effects of enalapril maleate against experimental supraventricular tachyarrhythmia in dogs by measuring cardiac troponin I levels
Authors: Kawaguchi, Takae Browse this author
Hashimoto, Rina Browse this author
Yasukawa, Yoko Browse this author
Yamada, Shusaku Browse this author
Yoshimura, Aritada Browse this author
Hirao, Daiki Browse this author
Omori, Takahiro Browse this author
Machida, Noboru Browse this author →KAKEN DB
Fukushima, Ryuji Browse this author →KAKEN DB
Keywords: cardiac troponin I
dog
enalapril maleate
supraventricular tachycardia arrhythmia
Issue Date: Nov-2019
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 67
Issue: 4
Start Page: 281
End Page: 294
Abstract: The development of ventricular systolic dysfunction in animals with supraventricular tachyarrhythmia (SVTA) has been reported to be largely due to myocardial injury, resulting from activation of the renin–angiotensin–aldosterone system. The objectives of this study were to demonstrate that the development of myocardial injury and the myocardial protective effect of enalapril maleate could be evaluated in a dog model of SVTA by measuring blood cardiac troponin I (cTnI) concentrations. Rapid atrial pacing (RAP) model dogs were divided into a Control group (no medication, n = 7) and an Enalapril group (enalapril maleate at 0.5 mg/kg once per day, n = 7). After 1, 2, and 3 weeks of RAP, significantly lower concentrations of cTnI were observed in the Enalapril group than in the Control group (P < 0.01). Upon histopathological examination of heart tissues, the control group showed more severe necrotic changes in myocardiocytes than the Enalapril group. In conclusion, this study demonstrated that both the development of myocardial injury and the myocardial protective effect of enalapril maleate could be assessed by measuring blood cTnI concentrations in SVTA model dogs. The results indicate that such measurements could comprise a useful method to diagnose myocardial injury and determine the therapeutic effect of a drug not only in human medicine but also in the veterinary field.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/76205
Appears in Collections:Japanese Journal of Veterinary Research > Volume 67 Number 4

Submitter: 獣医学部図書室

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