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Volume 67 Number 4 >

Age-related changes in bone morphology, function, and cell populations in inbred C57BL/6N mice

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Title: Age-related changes in bone morphology, function, and cell populations in inbred C57BL/6N mice
Authors: Namba, Takashi Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Nakamura, Teppei Browse this author
Masum, Md. Abdul Browse this author
Otani, Yuki Browse this author
Otsuka-Kanazawa, Saori Browse this author →KAKEN DB
Elewa, Yaser Hosny Ali Browse this author →ORCID
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: aging
Issue Date: Nov-2019
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 67
Issue: 4
Start Page: 313
End Page: 317
Abstract: Bones play crucial roles in controlling motility, regulating electrolyte metabolism, and hematopoiesis. We examined age-related changes in bone morphofunction using 3-, 6-, and 13-month-old male C57BL/6N mice. Tibia weight and length generally increased with age. Phosphorus, hemoglobin, and hematocrit measurements in blood, indices of electrolyte metabolism and hematopoiesis, significantly decreased with age. Bone histology showed that osteocyte and osteoblast numbers in the tibia were significantly correlated with decreases in hemoglobin levels and hematocrit values. Furthermore, platelet levels in blood increased with age, negatively correlating with osteoblast and osteoclast number. Thus, we have demonstrated age-related changes in bone morphofunction in healthy mice, particularly quantitative alternations of bone-composing cells and hematopoietic activities.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 67 Number 4

Submitter: 獣医学部図書室

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