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Potential of Gouda cheese whey to improve epidermal conditions by regulating proliferation and differentiation of keratinocytes

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Title: Potential of Gouda cheese whey to improve epidermal conditions by regulating proliferation and differentiation of keratinocytes
Authors: Shinagawa, Futa Browse this author
Takata, Sayuri Browse this author
Toba, Yu Browse this author
Ikuta, Minoru Browse this author
Hioki, Shoji Browse this author
Suzuki, Takahiro Browse this author
Nishimura, Takanori Browse this author →KAKEN DB
Nakamura, Ryosuke Browse this author
Kobayashi, Ken Browse this author →KAKEN DB
Issue Date: Dec-2018
Publisher: Elsevier
Journal Title: International dairy journal
Volume: 87
Start Page: 100
End Page: 106
Publisher DOI: 10.1016/j.idairyj.2018.07.016
Abstract: Sweet whey is a by-product of rennet-type cheese and contains abundant physiologically active substances. In this study, we investigated the effects of sweet whey on keratinocytes in mouse back skins using the warm-bathing model and using human keratinocyte culture model. The low-molecular-mass fraction (less than 3 kDa) of the whey was used for human keratinocyte culture because hydrophilic low mass components can penetrate into the epidermis. The two experimental models revealed that whey treatment activated the proliferation of keratinocytes. Whey treatment also up-regulated the expression of CK10, a marker for differentiated keratinocytes. The expression of epidermal tight junction proteins and aquaporin 3 (AQP3) was also activated by whey treatment expression. Whey contains abundant lactose and calcium. However, neither lactose nor calcium affected proliferation activity and AQP3 expression in cultured keratinocytes. These findings suggest that cheese whey may have potential as a cosmetic ingredient to improve epidermal conditions.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 謙

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