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Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin

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Title: Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin
Authors: Tanaka, Seiya Browse this author
Oyama, Manami Browse this author
Nishikawa, Miyu Browse this author →KAKEN DB
Ikushiro, Shinichi Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Keywords: Quercetin
glucuronide
sulfate
conjugation
porto-venous difference
Issue Date: 2-Dec-2018
Publisher: Taylor & Francis
Journal Title: Bioscience biotechnology and biochemistry
Volume: 82
Issue: 12
Start Page: 2118
End Page: 2129
Publisher DOI: 10.1080/09168451.2018.1515615
PMID: 30200823
Abstract: Quercetin is a flavonoid with many physiological effects. Absorbed quercetin is rapidly conjugated in the intestinal epithelium and liver. Different positional isomers of quercetin conjugates have different physiological properties. However, the mechanisms of quercetin conjugation in the intestine are not fully clarified. We examined the regioselective quercetin conjugate formation in the intestine after oral administration of quercetin glycosides, by simultaneous sampling of blood from the portal vein and superior vena cava, and quantifying various positional isomers of quercetin glucuronides and sulfates in conscious rats. Concentrations of quercetin glucuronides were higher in blood from the portal vein than the superior vena cava, showing that glucuronidation mainly occurred in the intestine. Such differences were not observed for quercetin sulfates. Regioselectivity of the intestinal glucuronidation in quercetin hydroxyl groups were 7->3'->3->4'-OH. Quercetin was mainly sulfated on 3'-OH at 30 min, but on 4'-OH at 240 min.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience Biotechnology and Biochemistry on 10 Sep 2018, available online: shttps://doi.org/10.1080/09168451.2018.1515615
Type: article (author version)
URI: http://hdl.handle.net/2115/76243
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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