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Serodiagnosis of elephant tuberculosis: a useful tool for early identification of infected elephants at the captive-wild interface

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/76245

Title: Serodiagnosis of elephant tuberculosis: a useful tool for early identification of infected elephants at the captive-wild interface
Authors: Paudel, Sarad Browse this author
Mikota, Susan K. Browse this author
Thapa, Jeewan Browse this author
Lyashchenko, Konstantin P. Browse this author
Gairhe, Kamal P. Browse this author
Dhakal, Ishwari Prasad Browse this author
Subedi, Naresh Browse this author
Maharjan, Bhagwan Browse this author
Subedi, Suraj Browse this author
Kaufman, Gretchen E. Browse this author
Tsubota, Toshio Browse this author →KAKEN DB
Keywords: Asian elephants
Tuberculosis
DPP VetTB assay
ElephantTB STAT-PAK
Serological assay
Issue Date: Dec-2018
Publisher: Springer
Journal Title: European journal of wildlife research
Volume: 64
Issue: 6
Start Page: 70
Publisher DOI: 10.1007/s10344-018-1229-3
Abstract: Tuberculosis (TB) is an emerging disease in elephants primarily caused by Mycobacterium tuberculosis (M. tb) and in some occassion by M. bovis. We performed culture and three serological teststhe Elephant TB STAT-PAK,(R) DPP VetTB (R) Assay, and MAPIA (multi-antigen print immunoassay)prospectively on samples from eight elephants in Nepal that died of suspected or confirmed tuberculosis (TB) between 2007 and 2013. Among them, all elephants were reactive to DPP VetTB (R) Assay, five to Elephant TB STAT-PAK,(R) and two were reactive to MAPIA. Similarly, six elephants were positive on culture on samples collected antemortem or postmortem. We observed antibody responses months to years before culture confirmation of TB which shows that serological tests can be highly useful for the early diagnosis of TB in elephants. Validated point-of-care serological tests are easily performed in the field and hold promise for improved TB surveillance in other non-domestic species.
Type: article (author version)
URI: http://hdl.handle.net/2115/76245
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坪田 敏男

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