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Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children : The Hokkaido Study

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Title: Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children : The Hokkaido Study
Authors: Bamai, Yu Ait Browse this author →KAKEN DB
Bastiaensen, Michiel Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Ito, Sachiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Yao, Yiming Browse this author
Covaci, Adrian Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Organophosphate flame retardant (PFR)
Urinary metabolites
Oxidative stress biomarkers
Multiple exposures
Issue Date: Oct-2019
Publisher: Elsevier
Journal Title: Environment international
Volume: 131
Start Page: UNSP 105003
Publisher DOI: 10.1016/j.envint.2019.105003
Abstract: Organophosphate flame retardants (PFRs) are used as additives in plastics and other applications such as curtains and carpets as a replacement for brominated flame retardants. As such, exposure to PFR mixtures is widespread, with children being more vulnerable than adults to associated health risks such as allergies and inflammation. Oxidative stress is thought to be able to modulate the development of childhood airway inflammation and atopic dermatitis. To evaluate these associations, the present study investigated the relationship between urinary PFR metabolites, their mixtures and urinary oxidative stress biomarkers in children as part of the Hokkaido Study on Environment and Children's Health. The levels of the oxidative stress biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), hexanoyl-lysine (HEL), and 4-hydroxynonenal (HNE), and of 14 PFR metabolites were measured in morning spot urine samples of 7-year-old children (n = 400). Associations between PFR metabolites or PFR metabolite mixtures and oxidative stress biomarkers were examined by multiple regression analysis and weighted quantile sum regression analysis, respectively. We found that the non-chlorinated PFR metabolites, 2-ethylhexyl phenyl phosphate (EHPHP), bis(2-butoxyethyl) phosphate (BBOEP), and diphenyl phosphate (DPHP) were associated with increased levels of oxidative stress biomarkers. Furthermore, the PFR metabolite mixture was associated with increased levels of HEL and HNE, but not 8-OHdG. The combination of elevated top 2 PFR metabolites was not associated with higher urinary oxidative stress marker levels. This is the first study to report associations between urinary PFR metabolites and oxidative stress biomarkers among children.
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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