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Ability of higenamine and related compounds to enhance glucose uptake in L6 cells

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Title: Ability of higenamine and related compounds to enhance glucose uptake in L6 cells
Authors: Kato, Eisuke Browse this author →KAKEN DB
Kimura, Shunsuke Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: β2-Adrenergic receptor
Tetrahydroisoquinoline
Glucose uptake
Muscle cell
Diabetes
Issue Date: 15-Dec-2017
Publisher: Elsevier
Journal Title: Bioorganic and Medicinal Chemistry
Volume: 25
Issue: 24
Start Page: 6412
End Page: 6416
Publisher DOI: 10.1016/j.bmc.2017.10.011
PMID: 29066136
Abstract: β2-Adrenergic receptor (β2AR) agonists are employed as bronchodilators to treat pulmonary disorders, but are attracting attention for their modulation of glucose handling and energy expenditure. Higenamine is a tetrahydroisoquinoline present in several plant species and has β2AR agonist activity, but the involvement of each functional groups in β2AR agonist activity and its effectiveness compared with endogenous catecholamines (dopamine, epinephrine, and norepinephrine) has rarely been studied. Glucose uptake of muscle cells are known to be induced through β2AR activation. Here, the ability to enhance glucose uptake of higenamine was compared with that of several methylated derivatives of higenamine or endogenous catecholamines. We found that: (i) the functional groups of higenamine except for the 4'-hydroxy group are required to enhance glucose uptake; (ii) higenamine shows a comparable ability to enhance glucose uptake with that of epinephrine and norepinephrine; (iii) the S-isomer shows a greater ability to enhance glucose uptake compared with that of the R-isomer.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/76323
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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