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Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016

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Title: Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
Authors: Wang, Jing Browse this author
Hu, Tao Browse this author
Sun, Dapeng Browse this author
Ding, Shujun Browse this author
Carr, Michael J. Browse this author →KAKEN DB
Xing, Weijia Browse this author
Li, Shixue Browse this author
Wang, Xianjun Browse this author
Shi, Weifeng Browse this author
Issue Date: 21-Aug-2017
Publisher: Nature Publishing Group
Journal Title: Scientific Reports
Volume: 7
Issue: 1
Start Page: 8900
Publisher DOI: 10.1038/s41598-017-09196-z
PMID: 28827733
Abstract: In the past decade, hand, foot, and mouth disease (HFMD) has posed a serious threat to childhood health in China; however, no epidemiological data from large HFMD epidemics have been described since 2013. In the present study, we described the epidemiological patterns of HFMD in Shandong province during 2009-2016 from a large number of symptomatic cases (n = 839,483), including >370,000 HFMD cases since 2013. Our results revealed that HFMD activity has remained at a high level and continued to cause annual epidemics in Shandong province from 2013 onwards. Although the incidence rate was significantly higher in urban areas than in rural areas, no significantly higher case-severity and case-fatality rates were found in urban areas. Furthermore, the seventeen cities of Shandong province could be classified into three distinct epidemiological groups according to the different peak times from southwest (inland) to northeast (coastal) regions. Notably, a replacement of the predominant HFMD circulating agent was seen and non-EVA71/Coxsackievirus A16 enteroviruses became dominant in 2013 and 2015, causing approximately 30% of the severe cases. Our study sheds light on the latest epidemiological characteristics of HFMD in Shandong province and should prove helpful for the prevention and control of the disease in Shandong and elsewhere.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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