HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Volume-based parameters on FDG PET may predict the proliferative potential of soft-tissue sarcomas

Files in This Item:
AnnNuclMed33 22.pdf636.02 kBPDFView/Open
supplementalfiggure10827.pptxSupplementary material48.68 kBMicrosoft Powerpoint XMLView/Open
Please use this identifier to cite or link to this item:

Title: Volume-based parameters on FDG PET may predict the proliferative potential of soft-tissue sarcomas
Authors: Kitao, Tomoka Browse this author
Shiga, Tohru Browse this author →KAKEN DB
Hirata, Kenji Browse this author →KAKEN DB
Sekizawa, Mitsunori Browse this author
Takei, Toshiki Browse this author
Yamashiro, Katsushige Browse this author
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Soft tissue sarcoma
Issue Date: Jan-2019
Publisher: Springer
Journal Title: Annals of nuclear medicine
Volume: 33
Issue: 1
Start Page: 22
End Page: 31
Publisher DOI: 10.1007/s12149-018-1298-0
Abstract: Introduction: Soft-tissue sarcomas (STS) are rare types of tumors that have variable levels of tumor differentiation. F-18 fluorodeoxyglucose positron emission tomography (FDG PET) has been established as an useful tool for STS patients, and the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are reported to be useful in various cancers. We compared the diagnostic value of four PET parameters (maximum standardized uptake value [SUVmax], SUVmean, MTV, and TLG) from two acquisition timings for predicting the expression of the pathological marker of cell proliferation Ki-67, based on pathological investigation. Materials and methods: In this retrospective study, we investigated 20 patients (59±19 years old, 18-87 years old) with pathologically confirmed STS who underwent FDG PET before surgical intervention. The patients fasted ≥6 h before the intravenous injection of FDG. The whole body was scanned twice; at an early phase (61.5±2.6 min) and at a delayed phase (118.0±2.1 min) post-injection. The SUVmax, SUVmean, MTV, and TLG of the primary lesion were measured with a tumor boundary determined by SUV ≥2.0. Ki-67 was measured using MIB-1 immunohistochemistry. We used Pearson's correlation coefficient to analyze the relationships between the PET parameters and Ki-67 expressions. The Kaplan-Meier analysis with the log-rank test was performed to compare overall survival between high-group and low-group at each of the four PET parameters and Ki-67 expression. Results: All four PET parameters at each phase showed significant correlations with Ki-67. Among them, the Pearson's correlation coefficient (r) was largest for TLG (r=0.76 and 0.77 at the early and delayed phases, respectively), followed by MTV (0.70 and 0.72), SUVmax (r=0.65 and 0.66), and SUVmean (r=0.62 and r=0.64). From early to delayed phases, the SUVmax and SUVmean both increased in all 20 patients, whereas the MTV and TLG increased in 13/20 (65%) and 16/20 (80%) patients, respectively. None of the %increases of the PET parameters were significantly correlated with Ki-67. The overall survival was shorter for high-SUVmax, high-SUVmean, high-TLG, and high-Ki-67 groups than the other groups, although the difference did not reach statistical significance. Conclusion: The SUVmax, SUVmean, MTV, and TLG acquired at both 1 and 2 h after injection showed significant correlations with Ki-67. Among them, correlation coefficient with Ki-67 expression was highest for TLG, although the best parameter should be determined in a larger population. The delayed-phase FDG PET was equally useful as that of early-phase to predict tumor aggressiveness in STS.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 健司

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


Feedback - Hokkaido University