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Associations between cognitive impairment and quality of life in euthymic bipolar patients

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Title: Associations between cognitive impairment and quality of life in euthymic bipolar patients
Authors: Toyoshima, Kuniyoshi Browse this author
Kako, Yuki Browse this author →KAKEN DB
Toyomaki, Atsuhito Browse this author →KAKEN DB
Shimizu, Yusuke Browse this author
Tanaka, Teruaki Browse this author
Nakagawa, Shin Browse this author →KAKEN DB
Inoue, Takeshi Browse this author →KAKEN DB
Martinez-Aran, Anabel Browse this author
Vieta, Eduard Browse this author
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Bipolar disorder
Cognitive complaints
Cognitive function
Neuropsychological assessment
COBRA
SF-36v2
SDS
Issue Date: Jan-2019
Publisher: Elsevier
Journal Title: Psychiatry research
Volume: 271
Start Page: 510
End Page: 515
Publisher DOI: 10.1016/j.psychres.2018.11.061
PMID: 30551083
Abstract: During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Forty patients in remission were recruited from the Hokkaido University Hospital, Sapporo, Japan and assessed with the translated version of the cognitive complaints in bipolar disorder rating assessment (COBRA), medical outcomes study 36-item short-form health survey version 2 (SF-36v2), and Sheehan disability scale (SDS). The Japanese adult reading scale, Wisconsin card sorting test, word fluency, continuous performance test, trail making test (TMT), auditory verbal learning, and Stroop test evaluated objective cognitive functions. Significant correlations were observed between the COBRA, SF-36v2, and SDS results, as well as the TMT scores. Overall, euthymic patients were aware of their cognitive dysfunction, which could be understood in relation to the decrease in satisfaction in their daily life. Therefore, even mild cognitive impairments can have ramifications for patients in the euthymic state of bipolar disorder.
Rights: ©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/76442
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 豊島 邦義

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