HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >

Exposures of children to neonicotinoids in pine wilt disease control areas

Files in This Item:
Environmental toxicology and chemistry38(1)_71_79.pdf380.5 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Exposures of children to neonicotinoids in pine wilt disease control areas
Authors: Ikenaka, Yoshinori Browse this author →KAKEN DB
Miyabara, Yuichi Browse this author
Ichise, Takahiro Browse this author
Nakayama, Shouta Browse this author
Nimako, Collins Browse this author
Ishizuka, Mayumi Browse this author
Tohyama, Chiharu Browse this author
Keywords: Insecticide
Hazard/risk assessment
Pesticide risk assessment
Estimated daily intake
Issue Date: Jan-2019
Publisher: John Wiley & Sons
Journal Title: Environmental toxicology and chemistry
Volume: 38
Issue: 1
Start Page: 71
End Page: 79
Publisher DOI: 10.1002/etc.4316
Abstract: Neonicotinoid insecticides that have been on the market since 1992 have been used globally including in Japan. Because they are sprayed over forests and agricultural areas, inadvertent toxicity in nontarget insects (especially honey bees) and humans is a matter of public concern. However, information on exposure levels and potential health impacts of neonicotinoids in children living around sprayed areas is scarce. Thus, we determined neonicotinoid exposure levels in children living in communities where thiacloprid was used to control pine wilt disease. A total of 46 children (23 males and 23 females) were recruited for the present study, and informed written consent was obtained from their guardians. Urine specimens were collected before, during, and after insecticide spraying events; and atmospheric particulate matter was also collected. Concentrations of thiacloprid and 6 other neonicotinoid compounds were determined in urine samples and in atmospheric particulate matter specimens using liquid chromatography-electrospray ionization-tandem mass spectrometry. In urine specimens, thiacloprid concentrations were <0.13 mu g/L and were detectable in approximately 30% of all samples. Concentrations of the other neonicotinoids, N-dm-acetamiprid, thiamethoxam, dinotefuran, and clothianidin, were 18.7, 1.92, 72.3, and 6.02 mu g/L, respectively. Estimated daily intakes of these neonicotinoids were then calculated from urinary levels; although the estimated daily intakes of the neonicotinoids were lower than current acceptable daily intake values, the children were found to be exposed to multiple neonicotinoids on a daily basis. Environ Toxicol Chem 2019;38:71-79. (c) 2018 SETAC
Rights: This is the peer reviewed version of the following article:, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 池中 良徳

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University