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Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study

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Title: Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study
Authors: Zhao, Jingge Browse this author
Matsuba, Takashi Browse this author →KAKEN DB
Zhang, Xiaoyan Browse this author
Leano, Susan Browse this author
Nakajima, Chie Browse this author →KAKEN DB
Chagan-Yasutan, Haorile Browse this author →KAKEN DB
Telan, Elizabeth Freda Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Hattori, Toshio Browse this author →KAKEN DB
Keywords: Mycobacterium tuberculosis
Dimorphic antigen
Rv0679c
Beijing genotype
Philippines
Immunoglobulin G
Immunoglobulin A
Issue Date: 15-May-2017
Publisher: BioMed Central
Journal Title: BMC Infectious Diseases
Volume: 17
Issue: 1
Start Page: 344
Publisher DOI: 10.1186/s12879-017-2442-5
PMID: 28506215
Abstract: Background:Strains of the Beijing genotype ofMycobacterium tuberculosis(MTB) are reportedly associated with thevirulence of tuberculosis (TB) infection, unfavorable outcomes of anti-TB treatment, and the global TB pandemic.Rv0679c, a hypothetical membrane protein related to host cell invasion, has a Beijing genotype-specific mutation atresidue 142 (Asn142Lys). Antigenicity differences between Rv0679c-Asn142 (N-type) and Rv0679c-Lys142 (K-type)have been previously observed in mice antigen-antibody responses. However, the immune response to Rv0679c inhumans remains unknown. Therefore, we aimed to investigate the anti-Rv0679c immune response in TB patientsfrom the endemic and non-endemic regions of the Beijing MTB genotype.Methods:We analyzed the Rv0679c-specific antibody responses in 84 subjects from the endemic region of the Beijinggenotype MTB in China, including 45 pulmonary TB patients (C-PTB) and 39 healthy controls (C-HC), and 81 subjectsfrom the Philippines (the endemic region of the non-Beijing genotype), including 51 pulmonary TB patients (P-PTB)and 30 healthy controls (P-HC). Anti-tuberculous-glycolipid (TBGL) antigen was used as the control antibody.Results:TBGL IgG titers were higher in both C-PTB and P-PTB than those in their corresponding HC (C-PTB median 4.2,P-PTB median 11.2; C-PTB vs. P-PTB,p> 0.05), suggesting immune response comparability in PTB from two differentcountries. C-PTB showed a higher response compared to C-HC for anti-K-type IgG (53.3%) than anti-N-type IgG (6.67%);this response was not observed in P-PTB (both N-type and K-type 9.80%).Conclusion:Dimorphic antigen Rv0679c was found to be associated with distinct immune response patterns,indicating the role of Beijing/non-Beijing genotype of MTB in stimulating specific responses in TB patients from theendemic region of Beijing MTB. Meanwhile, reactions to Rv0679c in patients and HC from non-endemic regions of theBeijing MTB may be caused by the response to the common epitope of Rv0679c N/K-type.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/76483
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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