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Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.

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Title: Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Authors: Kato, Tatsuya Browse this author
Lee, Daiyoon Browse this author
Wu, Licun Browse this author
Patel, Priya Browse this author
Young, Ahn Jin Browse this author
Wada, Hironobu Browse this author →KAKEN DB
Hu, Hsin-Pei Browse this author
Ujiie, Hideki Browse this author
Kaji, Mitsuhito Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Matsuge, Shinichi Browse this author
Domen, Hiromitsu Browse this author
Kaga, Kichizo Browse this author →KAKEN DB
Matsui, Yoshiro Browse this author →KAKEN DB
Kanno, Hiromi Browse this author
Hatanaka, Yutaka Browse this author →KAKEN DB
Hatanaka, Kanako C. Browse this author
Matsuno, Yoshihiro Browse this author →KAKEN DB
de Perrot, Marc Browse this author
Yasufuku, Kazuhiro Browse this author →KAKEN DB
Keywords: KIF11 (Eg5)
therapeutic target genes
malignant pleural mesothelioma
Issue Date: Aug-2016
Publisher: D.A. Spandidos
Journal Title: International journal of oncology
Volume: 49
Issue: 2
Start Page: 448
End Page: 456
Publisher DOI: 10.3892/ijo.2016.3566
PMID: 27279560
Abstract: Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative reverse transcription-polymerase chain reaction (RT-PCR) and an RNA interference-based screening, we screened two kinesin family members as potential therapeutic targets for MPM. Following in vitro investigation of the target silencing effects on MPM cells, a total of 53 MPMs were analyzed immunohistochemically with tissue microarray. KIF11 and KIF23 transcripts were found to be overexpressed in the majority of clinical MPM samples as well as human MPM cell lines as determined by quantitative RT-PCR. Gene knockdown in MPM cell lines identified growth inhibition following knockdown of KIF11 and KIF23. High expression of KIF11 (KIF11-H) and KIF23 (KIF23-H) were found in 43.4 and 50.9% of all the MPM cases, respectively. Patients who received curative resection with tumors displaying KIF23-H showed shorter overall survival (P=0.0194). These results provide that inhibition of KIF11 and KIF23 may hold promise for treatment of MPMs, raising the possibility that kinesin-based drug targets may be developed in the future.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 氏家 秀樹

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