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Track Structure Study for Energy Dependency of Electrons and X-rays on DNA Double-Strand Break Induction

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Title: Track Structure Study for Energy Dependency of Electrons and X-rays on DNA Double-Strand Break Induction
Authors: Yachi, Yoshie Browse this author
Yoshii, Yuji Browse this author
Matsuya, Yusuke Browse this author
Mori, Ryosuke Browse this author
Oikawa, Joma Browse this author
Date, Hiroyuki Browse this author →KAKEN DB
Issue Date: 27-Nov-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Start Page: 17649
Publisher DOI: 10.1038/s41598-019-54081-6
PMID: 31776470
Abstract: Radiation weighting factor w(R) for photons and electrons has been defined as unity independently of the energy of the particles. However, the biological effects depend on the incident energies according to in vitro experimental data. In this study, we have quantified the energy concentration along electron tracks in terms of dose-mean lineal energy (y(D)) on chromosome (micro-meter) and DNA (nano-meter) order scales by Monte Carlo simulations, and evaluated the impact of photon energies on DNA double-strand break (DNA-DSB) induction from an experimental study of irradiated cells. Our simulation result shows that the y(D) values for diagnostic X-rays (60-250 kVp) are higher than that for therapeutic X-rays (linac 6 MV), which agrees well with the tissue equivalent proportional counter (TEPC) measurements. The relation between the y(D) values and the numbers of gamma-H2AX foci for various photon energy spectra suggests that low energy X-rays induce DNA-DSB more efficiently than higher energy X-rays even at the same absorbed dose (e.g., 1.0 Gy). The relative biological effectiveness based on DNA-DSBs number (RBEDSB) is proportionally enhanced as the y(D) value increases, demonstrating that the biological impact of the photon irradiation depends on energy concentration along radiation tracks of electrons produced in the bio-tissues. Ultimately, our study implies that the value of w(R) for photons varies depending on their energies.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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