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Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-beta pathologies in a mouse model of Alzheimer's disease

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Title: Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-beta pathologies in a mouse model of Alzheimer's disease
Authors: Yuyama, Kohei Browse this author →KAKEN DB
Takahashi, Kaori Browse this author
Usuki, Seigo Browse this author
Mikami, Daisuke Browse this author
Sun, Hui Browse this author
Hanamatsu, Hisatoshi Browse this author
Furukawa, Junichi Browse this author
Mukai, Katsuyuki Browse this author
Igarashi, Yasuyuki Browse this author
Issue Date: 14-Nov-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Start Page: 16827
Publisher DOI: 10.1038/s41598-019-53394-w
Abstract: The accumulation of amyloid-beta protein (A beta) in brain is linked to the early pathogenesis of Alzheimer's disease (AD). We previously reported that neuron-derived exosomes promote A beta clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulated by ceramide metabolism. Here, we demonstrate that plant ceramides derived from Amorphophallus konjac, as well as animal-derived ceramides, enhanced production of extracellular vesicles (EVs) in neuronal cultures. Oral administration of plant glucosylceramide (GlcCer) to APP overexpressing mice markedly reduced A beta levels and plaque burdens and improved cognition in aY-maze learning task. Moreover, there were substantial increases in the neuronal marker NCAM-1, L1CAM, and A beta in EVs isolated from serum and brain tissues of the GlcCer-treated AD model mice. Our data showing that plant ceramides prevent A beta accumulation by promoting EVs-dependent A beta clearance in vitro and in vivo provide evidence for a protective role of plant ceramides in AD. Plant ceramides might thus be used as functional food materials to ameliorate AD pathology.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/76594
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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