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Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-beta pathologies in a mouse model of Alzheimer's disease
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| Title: | Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-beta pathologies in a mouse model of Alzheimer's disease |
| Authors: | Yuyama, Kohei Browse this author →KAKEN DB | | Takahashi, Kaori Browse this author | | Usuki, Seigo Browse this author | | Mikami, Daisuke Browse this author | | Sun, Hui Browse this author | | Hanamatsu, Hisatoshi Browse this author | | Furukawa, Junichi Browse this author | | Mukai, Katsuyuki Browse this author | | Igarashi, Yasuyuki Browse this author |
| Issue Date: | 14-Nov-2019 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 9 |
| Start Page: | 16827 |
| Publisher DOI: | 10.1038/s41598-019-53394-w |
| Abstract: | The accumulation of amyloid-beta protein (A beta) in brain is linked to the early pathogenesis of Alzheimer's disease (AD). We previously reported that neuron-derived exosomes promote A beta clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulated by ceramide metabolism. Here, we demonstrate that plant ceramides derived from Amorphophallus konjac, as well as animal-derived ceramides, enhanced production of extracellular vesicles (EVs) in neuronal cultures. Oral administration of plant glucosylceramide (GlcCer) to APP overexpressing mice markedly reduced A beta levels and plaque burdens and improved cognition in aY-maze learning task. Moreover, there were substantial increases in the neuronal marker NCAM-1, L1CAM, and A beta in EVs isolated from serum and brain tissues of the GlcCer-treated AD model mice. Our data showing that plant ceramides prevent A beta accumulation by promoting EVs-dependent A beta clearance in vitro and in vivo provide evidence for a protective role of plant ceramides in AD. Plant ceramides might thus be used as functional food materials to ameliorate AD pathology. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76594 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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