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Recombination and purifying and balancing selection determine the evolution of major antigenic protein 1 (map 1) family genes in Ehrlichia ruminantium
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| Title: | Recombination and purifying and balancing selection determine the evolution of major antigenic protein 1 (map 1) family genes in Ehrlichia ruminantium |
| Authors: | Salim, Bashir Browse this author | | Amin, Mutaz Browse this author | | Igarashi, Manabu Browse this author | | Ito, Kimihito Browse this author | | Jongejan, Frans Browse this author | | Katakura, Ken Browse this author | | Sugimoto, Chihiro Browse this author | | Nakao, Ryo Browse this author →KAKEN DB |
| Keywords: | Ehrlichia ruminantium | | Heartwater | | Recombination | | Negative and balance selection | | map1 |
| Issue Date: | 30-Jan-2019 |
| Publisher: | Elsevier |
| Journal Title: | Gene |
| Volume: | 683 |
| Start Page: | 216 |
| End Page: | 224 |
| Publisher DOI: | 10.1016/j.gene.2018.10.028 |
| Abstract: | Heartwater is an economically important disease of ruminants caused by the tick-borne bacterium Ehrlichia ruminantium. The disease is present throughout sub-Saharan Africa as well as on several islands in the Caribbean, where it poses a risk of spreading onto the American mainland. The dominant immune response of infected animals is directed against the variable outer membrane proteins of E. ruminantium encoded by a polymorphic multigene family. Here, we examined the full-length sequence of the major antigenic protein 1 (map1) family genes in multiple E. ruminantium isolates from different African countries and the Caribbean, collected at different time points to infer the possible role of recombination breakpoint and natural selection. A high level of recombination was found particularly in map1 and map1-2. Evidence of strong negative purifying selection in map1 and balancing selection to maintain genetic variation across these samples from geographically distinct countries suggests host pathogen co-evolution. This co-evolution between the host and pathogen results in balancing selection by maintaining genetic diversity that could be explained by the demographic history of long-term pathogen pressure. This signifies the adaptive role and the molecular evolutionary forces underpinning E. ruminantium map1 multigene family antigenicity. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/76631 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 中尾 亮
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