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CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults

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Title: CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults
Authors: Joutoku, Zenta Browse this author
Onodera, Tomohiro Browse this author →KAKEN DB
Matsuoka, Masatake Browse this author →KAKEN DB
Homan, Kentaro Browse this author →KAKEN DB
Momma, Daisuke Browse this author →KAKEN DB
Baba, Rikiya Browse this author →KAKEN DB
Hontani, Kazutoshi Browse this author →KAKEN DB
Hamasaki, Masanari Browse this author
Matsubara, Shinji Browse this author
Hishimura, Ryosuke Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Issue Date: 26-Mar-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Start Page: 5165
Publisher DOI: 10.1038/s41598-019-41621-3
Abstract: Juvenile tissue healing is capable of extensive scarless healing that is distinct from the scar-forming process of the adult healing response. Although many growth factors can be found in the juvenile healing process, the molecular mechanisms of juvenile tissue healing are poorly understood. Here we show that juvenile mice deficient in the chemokine receptor CCR7 exhibit diminished large-scale healing potential, whereas CCR7-depleted adult mice undergo normal scar-forming healing similar to wild type mice. In addition, the CCR7 ligand CCL21 was transiently expressed around damaged cartilage in juvenile mice, whereas it is rarely expressed in adults. Notably, exogenous CCL21 administration to adults decreased scar-forming healing and enhanced hyaline-cartilage repair in rabbit osteochondral defects. Our data indicate that the CCL21/CCR7 axis may play a role in the molecular control mechanism of juvenile cartilage repair, raising the possibility that agents modulating the production of CCL21 in vivo can improve the quality of cartilage repair in adults. Such a strategy may prevent post-traumatic arthritis by mimicking the self-repair in juvenile individuals.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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