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Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner

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Title: Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner
Authors: Nakatani, Yuka Browse this author
Kiyonari, Hiroshi Browse this author
Kondo, Toru Browse this author →KAKEN DB
Keywords: Ecrg4
Neural stem cells (NSCs)
Issue Date: Feb-2019
Publisher: Company of Biologists
Journal Title: Development
Volume: 146
Issue: 4
Start Page: dev168120
Publisher DOI: 10.1242/dev.168120
Abstract: The self-renewal activity of neural stem cells (NSCs) has been suggested to decrease with aging, resulting in age-dependent declines in brain function, such as presbyopia and memory loss. The molecular mechanisms underlying decreases in NSC proliferation with age need to be elucidated in more detail to develop treatments that promote brain function. We have previously reported that the expression of esophageal cancer-related gene 4 (Ecrg4) was upregulated in aged NSCs, whereas its overexpression decreased NSC proliferation, suggesting a functional relationship between Ecrg4 and NSC aging. Using Ecrg4-deficient mice in which the Ecrg4 locus was replaced with the lacZ gene, we here show that Ecrg4 deficiency recovered the age-dependent decline in NSC proliferation and enhanced spatial learning and memory in the Morris water-maze paradigm. We demonstrate that the proliferation of Ecrg4-deficient NSCs was partly maintained by the increased expression of Foxg1. Collectively, these results determine Ecrg4 as a NSC aging factor.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 近藤 亨

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