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Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones : The Hokkaido Study on Environment and Children's Health

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Title: Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones : The Hokkaido Study on Environment and Children's Health
Authors: Baba, Toshiaki Browse this author
Ito, Sachiko Browse this author →KAKEN DB
Yuasa, Motoyuki Browse this author →KAKEN DB
Yoshioka, Eiji Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Hori, Tsuguhide Browse this author
Kato, Shizue Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Dioxins
PCBs
Thyroid hormones
Prenatal exposure
Birth cohort
Issue Date: 15-Feb-2018
Publisher: Elsevier
Journal Title: Science of The Total Environment
Volume: 615
Start Page: 1239
End Page: 1246
Publisher DOI: 10.1016/j.scitotenv.2017.09.038
Abstract: Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) are persistent organic pollutants that are universally detected. Some congeners of PCDDs, PCDFs or PCBs have dioxin-like toxicity, whereas non-dioxin-like PCBs are considered to have different toxicity. Reports of the relationships between prenatal exposure to PCDDs, PCDFs or PCBs and thyroid homeostasis in pregnant women and infants have been inconsistent. The aim of this study was to investigate the effect of maternal serum PCDD/F or PCB levels on maternal and neonatal thyroid hormone (TH) levels in a prospective cohort. Of the 514 subjects in the prospective cohort, 386 mothers and 410 infants were included for analysis. Fifteen dioxins and seventy PCBs in maternal blood collected between 23 and 41 weeks of gestation were measured using high-resolution gas chromatography and high-resolution mass spectrometry. Blood samples to measure thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers at an early gestational stage (median ten weeks), and from infants between four and seven days of age, respectively. Multiple linear regression analysis was conducted. Median concentration of total PCBs, PCB 153 were 104,700, and 20,500 pg/g lipid, respectively. Median total dioxin-TEQ was 13.8 pg/g lipid. Total dioxin-TEQ, coplanar PCBs were positively associated with neonatal FT4 (beta = 0.224, 0.206, respectively). The association was stronger in boys (beta = 0.299, 0.282, respectively). Several PCDD/F and PCB isomers were also positively associated with neonatal FT4. Total PCBs or non-dioxin-like PCBs were not associated with any maternal or neonatal THs. No DLC grouping or congeners were associated with neonatal TSH. Non-ortho PCBs were positively associated with maternal FT4. Three PCB congeners had significant positive association(s) with maternal THs. In conclusion, the results of our study suggest that perinatal exposure to background-level DLCs increases neonatal FT4, especially in boys.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/76744
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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