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Birth cohorts in Asia : The importance, advantages, and disadvantages of different-sized cohorts

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Title: Birth cohorts in Asia : The importance, advantages, and disadvantages of different-sized cohorts
Authors: Kishi, Reiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Keywords: Asia
birth cohort
sample size
dioxins
perfluoroalkyl substances
health outcomes
Issue Date: 15-Feb-2018
Publisher: Elsevier
Journal Title: Science of The Total Environment
Volume: 615
Start Page: 1143
End Page: 1154
Publisher DOI: 10.1016/j.scitotenv.2017.08.268
Abstract: Asia contains half of the world's children, and the countries of Asia are the most rapidly industrializing nations on the globe. Environmental threats to the health of children in Asia are myriad. Several birth cohorts were started in Asia in early 2000, and currently more than 30 cohorts in 13 countries have been established for study. Cohorts can contain from approximately 100-200 to 20,000-30,000 participants. Furthermore, national cohorts targeting over 100,000 participants have been launched in Japan and Korea. The aim of this manuscript is to discuss the importance of Asian cohorts, and the advantages and disadvantages of different-sized cohorts. As for case, one small-sized (n = 514) cohort indicate that even relatively low level exposure to dioxin in utero could alter birth size, neurodevelopment, and immune and hormonal functions. Several Asian cohorts focus prenatal exposure to perfluoroalkyo substances and reported associations with birth size, thyroid hormone levels, allergies and neurodevelopment. Inconsistent findings may possibly be explained by the differences in exposure levels and target chemicals, and by possible statistical errors. In a smaller cohort, novel hypotheses or preliminary examinations are more easily verifiable. In larger cohorts, the etiology of rare diseases, such as birth defects, can be analyzed; however, they require a large cost and significant human resources. Therefore, conducting studies in only one large cohort may not always be the best strategy. International collaborations, such as the Birth Cohort Consortium of Asia, would cover the inherent limitation of sample size in addition to heterogeneity of exposure, ethnicity, and socioeconomic conditions.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/76745
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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