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Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions

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Title: Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions
Authors: Takada, Shingo Browse this author →KAKEN DB
Okita, Koichi Browse this author →KAKEN DB
Suga, Tadashi Browse this author
Omokawa, Masashi Browse this author
Kadoguchi, Tomoyasu Browse this author
Sato, Takashi Browse this author
Takahashi, Masashige Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Hirabayashi, Kagami Browse this author
Morita, Noriteru Browse this author →KAKEN DB
Horiuchi, Masahiro Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: low-intensity training
all-out exertion
short-term exercise
adverse training effects
metabolic threshold
Issue Date: 2012
Publisher: American Physiological Society
Journal Title: Journal of Applied Physiology
Volume: 113
Issue: 2
Start Page: 199
End Page: 205
Publisher DOI: 10.1152/japplphysiol.00149.2012
Abstract: Skeletal muscle bulk and strength are becoming important therapeutic targets in medicine. To increase muscle mass, however, intensive, long-term mechanical stress must be applied to the muscles, and such stress is often accompanied by orthopedic and cardiovascular problems. We examined the effects of circulatory occlusion in resistance training combined with a very low-intensity mechanical load on enhancing muscular metabolic stress and thereby increasing muscle bulk. Muscular metabolic stress, as indicated by the increases in inorganic phosphate (Pi) and a decrease in intramuscular pH, was evaluated by 31P-magnetic resonance spectroscopy during unilateral plantar-flexion at 20% of the one-repetition maximum (1-RM) with circulatory occlusion for 2 min in 14 healthy, male untrained participants (22 yr) at baseline. Participants performed two sets of the same exercise with a 30-s rest between sets, 2 times/day, 3 days/wk, for 4 wk. The muscle cross-sectional area (MCA) of the plantar-flexors and the 1-RM were measured at baseline and after 2 and 4 wk of training. MCA and 1-RM were significantly increased after 2 and 4 wk (P < 0.05, respectively). The increase in MCA at 2 wk was significantly (P < 0.05) correlated with the changes in Pi (r = 0.876) and intramuscular pH (r = 0.601). Furthermore, the increases in MCA at 4 wk and 1-RM at 2 wk were also correlated with the metabolic stress. Thus enhanced metabolic stress in exercising muscle is a key mechanism for favorable effects by resistance training. Low-intensity resistance exercise provides successful outcomes when performed with circulatory occlusion, even with a short training period.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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