| Title: | Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice |
| Authors: | Takada, Shingo Browse this author →KAKEN DB |
| Kinugawa, Shintaro Browse this author →KAKEN DB |
| Hirabayashi, Kagami Browse this author |
| Suga, Tadashi Browse this author |
| Yokota, Takashi Browse this author →KAKEN DB |
| Takahashi, Masashige Browse this author |
| Fukushima, Arata Browse this author →KAKEN DB |
| Homma, Tsuneaki Browse this author |
| Ono, Taisuke Browse this author |
| Sobirin, Mochamad A. Browse this author |
| Masaki, Yoshihiro Browse this author |
| Mizushima, Wataru Browse this author |
| Kadoguchi, Tomoyasu Browse this author |
| Okita, Koichi Browse this author →KAKEN DB |
| Tsutsui, Hiroyuki Browse this author →KAKEN DB |
| Keywords: | oxidative stress |
| angiotensin |
| diabetes |
| mitochondria |
| muscle |
| Issue Date: | 2013 |
| Publisher: | American Physiological Society |
| Journal Title: | Journal of Applied Physiology |
| Volume: | 114 |
| Issue: | 7 |
| Start Page: | 844 |
| End Page: | 857 |
| Publisher DOI: | 10.1152/japplphysiol.00053.2012 |
| Abstract: | NAD(P)H oxidase-induced oxidative stress is at least in part involved with lowered exercise capacity and impaired mitochondrial function in high-fat diet (HFD)-induced diabetic mice. NAD(P)H oxidase can be activated by activation of the renin-angiotensin system. We investigated whether ANG II receptor blocker can improve exercise capacity in diabetic mice. C57BL/6J mice were fed a normal diet (ND) or HFD, and each group of mice was divided into two groups: treatment with or without olmesartan (OLM; 3 mg·kg−1·day−1 in the drinking water). The following groups of mice were studied: ND, ND+OLM, HFD, and HFD+OLM (n = 10 for each group). After 8 wk, HFD significantly increased body weight, plasma glucose, and insulin compared with ND, and OLM did not affect these parameters in either group. Exercise capacity, as determined by treadmill tests, was significantly reduced in HFD, and this reduction was ameliorated in HFD+OLM. ADP-dependent mitochondrial respiration was significantly decreased, and NAD(P)H oxidase activity and superoxide production by lucigenin chemiluminescence were significantly increased in skeletal muscle from HFD, which were attenuated by OLM. There were no such effects by OLM in ND. We concluded that OLM ameliorated the decrease in exercise capacity in diabetic mice via improvement in mitochondrial function and attenuation of oxidative stress in skeletal muscle. These data may have a clinical impact on exercise capacity in the medical treatment of diabetes mellitus. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76769 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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